Copyright ©The Author(s) 2017.
World J Hepatol. Feb 18, 2017; 9(5): 227-241
Published online Feb 18, 2017. doi: 10.4254/wjh.v9.i5.227
Figure 1
Figure 1 Effects of nucleos(t)ide analogues. A: NAs show antiviral effect by inhibition of hepatitis B virus (HBV) polymerase; B: NAs also inhibits human mitochondrial polymerase-γ enzyme. Thus, mitochondrial DNA (mtDNA) can not be synthesized. Oxidative phosphorylation is impaired. There are two consequences of this: Impaired energy production and increased reactive oxygen species that cause cellular damage. NAs: Nucleos(t)ide analogues.