Fractional excretion of sodium in hepatorenal syndrome: Clinical and pathological correlation

Figure 1 Receiver operator characteristics curve showing the poor accuracy of fractional excretion of sodium < 1% in diagnosing hepatorenal syndrome syndrome with area under the curve of 0. 58, P = 0.47-0.58. AUC: Area under the curve.

Figure 2 Correlation between fractional excretion of sodium as a continuous variable and kidney biopsy diagnosis. Although FeNa was lowest in HRS patients, it did not differentiate between HRS and other renal pathologies (P = 0.41). FeNa: Fractional excretion of sodium; HRS: Hepatorenal syndrome; ATN: Acute tubular necrosis; MGPN: Membranoproliferative glomerulonephritis; IF: Interstitial fibrosis; GS: Glomerulosclerosis.

Figure 3 Scatter plot depicting the relationship between the percentage of interstitial fibrosis on kidney biopsy and 24-h urine sodium excretion. Correlation was overall poor (r = 0.07, P = 0.54).

Figure 4 Scatter plot depicting the relationship between the percentage of glomerulosclerosis on kidney biopsy result and 24-h urine sodium excretion (r = 0. 2, P = 0.07). Correlation was better than the one observed with percentage of interstitial fibrosis but still did not reach statistical significance.