Role of systemic inflammation in cirrhosis: From pathogenesis to prognosis

Figure 1 Natural history of cirrhosis. The classical compensated and decompensated phases of cirrhosis are divided by the presence of specific complications and marked by stable progression. A possible shortcut may occur after a decompensating event in any phase of cirrhosis, hastening the development of organ failure and a worse prognosis; this syndrome is termed acute-on-chronic liver failure (ACLF).