Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis

Figure 1 Regenerative nodular hyperplasia. A: Magnetic resonance image of RNH (axial T1 FSE). Note the two hyperintense, solid nodules localized in the right hepatic lobe (arrows); B: Typical findings of a RNH lesion revealed by reticulin staining to highlight the sinusoidal architecture of the liver. Note the liver sinusoidal shrinking, mimicking a pseudonodule. RNH: Regenerative nodular hyperplasia.

Figure 2 (A) Macrosteatosis, (B) microsteatosis and (C) megamitochondria (arrows), in a non-alcoholic 27-year-old patient with active systemic lupus erythematosus, treated with steroids and methotrexate (H and E staining).