Multiple focal nodular hyperplasias induced by oxaliplatin-based chemotherapy

Figure 1 Radiological imaging of case 1. A: The abdominal contrast-enhanced magnetic resonance imaging showed multiple bilateral focal liver lesions (arrows); B: The fluorodeoxyglucose-positron emission tomography scan did not show any pathological uptake of the trace.

Figure 2 Histology of case 1. A: The gross inspection of the specimen showed lesions sized between 0.5 and 2 cm, with well-defined margins, and a central scar; B, C: At microscopy the lesions were characterized by several fibrous septa highlighted by special stains (Masson staining), and they showed a typical patter at glutamine synthetase immunostaining; D: At higher magnification they contained several dystrophic vessels.

Figure 3 Radiological imaging of case 2. A: The abdominal contrast-enhanced computed tomography showed multiple focal liver lesions (arrows); B: The fluorodeoxyglucose-positron emission tomography scan did not show any pathological uptake of the trace.