Original Article
Copyright ©2010 Baishideng.
World J Hepatol. Jan 27, 2010; 2(1): 32-41
Published online Jan 27, 2010. doi: 10.4254/wjh.v2.i1.32
Figure 1
Open in New Tab Full Size Figure Download Figure
Figure 1 Immunohistochemical staining for Cyclin D1 in liver sections of patients from the control group as well as HCV-infected patients and HCV-related HCC patients. A: Liver section from a control case showing mild nuclear staining for Cyclin D1 (arrows) (Immunoperoxidase × 40); B: Liver section from a case of CHC showing mild nuclear expression of Cyclin D1 (arrows). The portal tract is completely free from immunostaining (Immunoperoxidase × 40); C: Liver section from a case of LC showing moderate number of positively stained hepatocytes in a cirrhotic nodule (arrows) (Immunoperoxidase × 40); D: Liver section from a case of poorly-differentiated HCC showing marked nuclear expression of Cyclin D1 (arrows) (Immunoperoxidase × 40).
Figure 2
Open in New Tab Full Size Figure Download Figure
Figure 2 Immunohistochemical staining of liver sections from different differentiated HCC cases (Immunoperoxidase × 40). A: Well differentiated HCC showing moderate nuclear staining of cyclin E (arrows); B: Poorly-differentiated HCC showing marked nuclear staining of cyclin E (arrows); C: Well-differentiated HCC revealing nuclear expression of p21Cip1/Waf1 (arrows) in the hepatocytes; D: Poorly-differentiated HCC showing p27Kip1 expression in a mixed pattern (arrows).
Figure 3
Open in New Tab Full Size Figure Download Figure
Figure 3 Immunohistochemical staining for Rb1/p105 in liver sections of the control group patients as well as HCV-infected patients and HCV-related HCC patients. A: Liver section from a case of the control showing negative staining for Rb1/p105 either in the cytoplasm or in the nuclei of hepatocytes (IP × 20); B: Liver section from a case with CHC showing moderate nuclear expression for Rb1/p105 in the hepatocytes (long arrow) and in few scattered inflammatory cells (short arrow) of the portal tract (IP × 40); C: Liver section from a case with LC showing moderate nuclear expression for Rb1/p105 in hepatocytes (arrows) and some inflammatory cells of the portal tract in LC (IP × 20); D: Liver section from a case with poorly-differentiated HCC showing marked nuclear expression for Rb1/p105 in the hepatocytes (arrows) (IP × 40).