Response rates, survival status and adverse events of placebo in randomized control trials for hepatocellular carcinoma: A meta-analysis

Figure 1 PRISMA flow chart.

Figure 2 Forest plot of response rates in the placebo arm across the randomized controlled trials of hepatocellular carcinoma. A: Disease control rate in the placebo arm; B: Objective response rate in the placebo arm.

Figure 3 Forest plot of survival status in the placebo arm across the randomized controlled trials of hepatocellular carcinoma. A: Overall survival in the placebo arm; B: Progression-free survival in the placebo arm.

Figure 4 Forest plot of the incidence of adverse events in the placebo arm across the randomized controlled trials of hepatocellular carcinoma. A: Grade 3 or 4 adverse events (AEs) in the placebo arm; B: Interruption or reductions due to AEs in the placebo arm; C: Treatment discontinuation due to AEs in the placebo arm.

Figure 5 Subgroup analyses based on the treatment lines in placebo disease control rate.