Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients

Figure 1 Long-term changes in platelet counts and Fib4 scores prior to the establishment of cirrhosis. A: Patient 1, platelet counts; B: Patient 1, Fib4 scores; C: Patient 2, platelet counts; D: Patient 2, Fib4 scores. MRE: Magnetic resonance elastography.

Figure 2 Time-dependent changes in platelet counts and Fib-4 scores: Cohort averages. A: Biopsy cohort, platelet counts; B: Biopsy cohort, Fib4 scores; C: Magnetic resonance elastography (MRE) cohort, platelet counts; D: MRE cohort, Fib4 scores. Data are shown as mean + standard error. Fibrosis stages 0–4 are marked by the corresponding numerals. For magnetic resonance elastography data, “0” corresponds to a liver stiffness of < 2.9 kPa, “1” to 2.9-3.5 kPa, “2” to 3.5-4.0 kPa, “3” to 40–5.0 kPa, and “4” to > 5.0 kPa. MRE: Magnetic resonance elastography.

Figure 3 Time-dependent changes in platelet counts and Fib-4 scores: Stage 0 vs stage 4 fibrosis by liver biopsy. A: Stage 0 fibrosis, platelet counts; B: Stage 0 fibrosis, Fib4 scores; C: Stage 4 fibrosis, platelet counts; D: Stage 4 fibrosis, Fib4 scores.

Figure 4 Time-Dependent changes in platelet counts and Fib-4 scores: stage 0 vs stage 4 fibrosis by magnetic resonance elastography. A: Stage 0 fibrosis, platelet counts; B: Stage 0 fibrosis, Fib4 scores; C: Stage 4 fibrosis, platelet counts; D: Stage 4 fibrosis, Fib4 scores. MRE: Magnetic resonance elastography.