Secondary sclerosing cholangitis after critical COVID-19: Three case reports

Figure 1 Sclerosing cholangitis imaging findings. A: Cholangiogram showed dilatation of the common bile duct and its intrahepatic branches in the first case; B: Magnetic resonance imaging (MRI) demonstrated multiple short stenosis of the intrahepatic bile ducts; C and D: In the second and third case, the MRI showed multiple stenosis of the intrahepatic bile duct.

Figure 2 Histological findings. A: Histological sections of the liver (magnification 4 ×) stained with hematoxylin and eosin (H&E) showing mixed inflammatory infiltrate in portal spaces; B and C: H&E (magnification 10 ×) showing regenerative changes and swelling of cholangiocytes, as well as presence of inflammatory infiltrate in the portal space vein and hepatic artery; D and E: Intracanalicular and cytoplasmic cholestasis is observed predominantly in space 3, fibrosis in portal and periportal space (magnification 40 × and 10 ×, respectively); F: Immunohistochemistry for cytokeratin 7 (CK7) demonstrating CK7 metaplasia in hepatocytes and ductular reaction (magnification 40 ×).