Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease

Figure 1 CONSORT chart for inclusion of patients. AVB: Acute variceal bleeding; HE: Hepatic encephalopathy; PSM: Propensity score matching; FFP: Fresh frozen plasma; EHPVO: Extrahepatic portal vein obstruction; NCPF: Non-cirrhotic portal fibrosis; UGI: upper gastrointestinal; EVL: Endoscopic variceal ligation; GAVE: Gastric antral vascular ectasia; PHG: Phenylethanoid glycosides.

Figure 2 Kaplan Meier curves for the entire cohort of patients based on baseline platelet counts demonstrating cumulative probability. A: Free from rebleed (log-rank P = 0.396); B: Survival (log-rank P = 0.176).

Figure 3 Kaplan Meier curves of cumulative probability of free from rebleed in patients receiving platelets compared to those who did not. A: Overall cohort (log-rank P < 0.001); B: Platelet counts < 20 × 10⁹/L (log-rank P = 0.303); C: Platelet counts 20 × 10⁹/L-50 × 10⁹/L (log-rank P < 0.001); D: Platelet counts > 50 × 10⁹/L (log-rank P = 0.038).

Figure 4 Kaplan Meier curves of survival probability in patients based on whether they received platelet transfusions or not. A: Overall cohort (log rank P = 0.074), B: Platelet counts < 20 × 10⁹/L (log-rank P = 0.375); C: Platelet counts 20 × 10⁹/L-50 × 10⁹/L (log-rank P = 0.250); D: Platelet counts > 50 × 10⁹/L (log-rank P = 0.716).

Figure 5 Kaplan Meier curves of patients receiving platelets compared to those who did not in the PSM matched cohort demonstrating cumulative probability. A: Free from rebleed (log-rank P = 0.012); B: Survival probability (log-rank P = 0.755).