Cytomegalovirus infection in liver-transplanted children

Figure 1 Cytomegalovirus tissue infection of the stomach and duodenum in a 13-mo-old boy and a 14-year-old boy with D⁺/R⁻ serostatus at transplant. Neither patient received antiviral prophylaxis. A and B: The 13-mo-old boy with D⁺/R⁻ serostatus at transplant presented with severe anaemia at 3 mo; C and D: The 14-year-old boy presented with haematemesis at 2 mo after liver transplantation.

Figure 2 Biopsies showing chronic active gastritis. A: Cytomegalovirus inclusion bodies are seen within mucous cells. The gastric biopsy is characterized by enlarged cells with basophilic nuclear and cytoplasmic inclusions; B: Liver biopsy shows a neutrophilic microabscess surrounding a hepatocyte with granular basophilic cytoplasmic cytomegalovirus inclusions; C: Positive cytomegalovirus immunohistochemistry in liver tissue.