Systematic Review
Copyright ©The Author(s) 2019.
World J Hepatol. May 27, 2019; 11(5): 450-463
Published online May 27, 2019. doi: 10.4254/wjh.v11.i5.450
Figure 1
Figure 1 Molecular mechanisms of cholestasis at the apical hepatocellular membrane. FXR: Farnesoid X receptor; RXR: Retinoid x receptor alpha; ABCB11: ATP binding cassette subfamily B member 11; MYO5B: Myosin VB; RAB11A: Ras-related protein Rab11a; FIC1: Familial intrahepatic cholestasis 1; BSEP: Bile salt export pump; MDR3: Multidrug resistance 3; TJP2: Tight junction protein 2.
Figure 2
Figure 2 Representative surgical interventions for progressive familial cholestasis. A: Partial external biliary diversion; B: Partial internal biliary diversion using a cholecystocolostomy approach; C: Ileal bypass/exclusion.