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For: Wang Y, Cui F, Lv Y, Li C, Xu X, Deng C, Wang D, Sun Y, Hu G, Lang Z, Huang C, Yang X. HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology 2004;39:318-24. [PMID: 14767984 DOI: 10.1002/hep.20076] [Cited by in Crossref: 108] [Cited by in F6Publishing: 105] [Article Influence: 6.0] [Reference Citation Analysis]
Number Citing Articles
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2 Wang N, Zheng Y, Yu X, Lin W, Chen Y, Jiang Q. Sex-modified effect of hepatitis B virus infection on mortality from primary liver cancer. Am J Epidemiol 2009;169:990-5. [PMID: 19224979 DOI: 10.1093/aje/kwn418] [Cited by in Crossref: 17] [Cited by in F6Publishing: 14] [Article Influence: 1.3] [Reference Citation Analysis]
3 Xu C, Zhou W, Wang Y, Qiao L. Hepatitis B virus-induced hepatocellular carcinoma. Cancer Lett. 2014;345:216-222. [PMID: 23981576 DOI: 10.1016/j.canlet.2013.08.035] [Cited by in Crossref: 88] [Cited by in F6Publishing: 88] [Article Influence: 9.8] [Reference Citation Analysis]
4 Dai X, Zhang W, Zhang H, Sun S, Yu H, Guo Y, Kou Z, Zhao G, Du L, Jiang S. Modulation of HBV replication by microRNA-15b through targeting hepatocyte nuclear factor 1α. Nucleic Acids Res. 2014;42:6578-6590. [PMID: 24705650 DOI: 10.1093/nar/gku260] [Cited by in Crossref: 52] [Cited by in F6Publishing: 49] [Article Influence: 6.5] [Reference Citation Analysis]
5 Tatsukawa M, Takaki A, Shiraha H, Koike K, Iwasaki Y, Kobashi H, Fujioka S, Sakaguchi K, Yamamoto K. Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients. BMC Cancer 2011;11:458. [PMID: 22014121 DOI: 10.1186/1471-2407-11-458] [Cited by in Crossref: 19] [Cited by in F6Publishing: 17] [Article Influence: 1.7] [Reference Citation Analysis]
6 Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y. Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx. J Virol 2016;90:3530-42. [PMID: 26792738 DOI: 10.1128/JVI.02776-15] [Cited by in Crossref: 18] [Cited by in F6Publishing: 10] [Article Influence: 3.0] [Reference Citation Analysis]
7 Wu J, Zhang XJ, Shi KQ, Chen YP, Ren YF, Song YJ, Li G, Xue YF, Fang YX, Deng ZJ. Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells. Carcinogenesis. 2014;35:155-163. [PMID: 23917076 DOI: 10.1093/carcin/bgt268] [Cited by in Crossref: 27] [Cited by in F6Publishing: 28] [Article Influence: 3.0] [Reference Citation Analysis]
8 Cantarini MC, Trevisani F, Morselli-Labate AM, Rapaccini G, Farinati F, Del Poggio P, Di Nolfo MA, Benvegnù L, Zoli M, Borzio F, Bernardi M; Italian Liver Cancer (ITA.LI.CA) group. Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma. Am J Gastroenterol 2006;101:91-8. [PMID: 16405539 DOI: 10.1111/j.1572-0241.2006.00364.x] [Cited by in Crossref: 66] [Cited by in F6Publishing: 65] [Article Influence: 4.1] [Reference Citation Analysis]
9 Qiu X, Dong S, Qiao F, Lu S, Song Y, Lao Y, Li Y, Zeng T, Hu J, Zhang L. HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma. Oncogene. 2013;32:3296-3305. [PMID: 23604124 DOI: 10.1038/onc.2013.150] [Cited by in Crossref: 74] [Cited by in F6Publishing: 78] [Article Influence: 8.2] [Reference Citation Analysis]
10 Teng YC, Neo JC, Wu JC, Chen YF, Kao CH, Tsai TF. Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice. J Pathol 2017;241:463-74. [PMID: 27868197 DOI: 10.1002/path.4850] [Cited by in Crossref: 24] [Cited by in F6Publishing: 20] [Article Influence: 4.8] [Reference Citation Analysis]
11 Ahluwalia S, Choudhary D, Tyagi P, Kumar V, Vivekanandan P. Vitamin D signaling inhibits HBV activity by directly targeting the HBV core promoter. J Biol Chem 2021;297:101233. [PMID: 34562448 DOI: 10.1016/j.jbc.2021.101233] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
12 Chang K, Chang Y, Wang LH, Tsai H, Huang W, Su I. Pathogenesis of virus-associated human cancers: Epstein–Barr virus and hepatitis B virus as two examples. Journal of the Formosan Medical Association 2014;113:581-90. [DOI: 10.1016/j.jfma.2013.09.001] [Cited by in Crossref: 3] [Cited by in F6Publishing: 4] [Article Influence: 0.4] [Reference Citation Analysis]
13 Zhang XD, Wang Y, Ye LH. Hepatitis B virus X protein accelerates the development of hepatoma. Cancer Biol Med. 2014;11:182-190. [PMID: 25364579 DOI: 10.7497/j.issn.2095-3941.2014.03.004] [Cited by in F6Publishing: 42] [Reference Citation Analysis]
14 Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM, Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML. HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling. Sci Rep. 2016;6:23521. [PMID: 27009634 DOI: 10.1038/srep23521] [Cited by in Crossref: 84] [Cited by in F6Publishing: 84] [Article Influence: 14.0] [Reference Citation Analysis]
15 Yang Y, Gao J, Li HL, Zheng W, Yang G, Zhang W, Ma X, Tan YT, Rothman N, Gao YT. Dose-response association between hepatitis B surface antigen levels and liver cancer risk in Chinese men and women. Int J Cancer. 2016;139:355-362. [PMID: 26990915 DOI: 10.1002/ijc.30086] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 1.8] [Reference Citation Analysis]
16 Huang J, Wang Y, Guo Y, Sun S. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 2010;52:60-70. [PMID: 20578129 DOI: 10.1002/hep.23660] [Cited by in Crossref: 257] [Cited by in F6Publishing: 243] [Article Influence: 21.4] [Reference Citation Analysis]
17 Bharadwaj M, Roy G, Dutta K, Misbah M, Husain M, Hussain S. Tackling hepatitis B virus-associated hepatocellular carcinoma--the future is now. Cancer Metastasis Rev. 2013;32:229-268. [PMID: 23114844 DOI: 10.1007/s10555-012-9412-6] [Cited by in Crossref: 16] [Cited by in F6Publishing: 13] [Article Influence: 1.8] [Reference Citation Analysis]
18 Hung J, Yan C, Su I, Wang H, Lei H, Lin W, Chang W, Huang W, Lu T, Lai M. Hepatitis B virus surface antigen interacts with acid alpha-glucosidase and alters glycogen metabolism: HBV alters glycogen metabolism. Hepatology Research 2010;40:633-40. [DOI: 10.1111/j.1872-034x.2010.00645.x] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 0.5] [Reference Citation Analysis]
19 You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, Du Y, Kong G, Wang T, Ye L. Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene. 2014;33:449-460. [PMID: 23318446 DOI: 10.1038/onc.2012.618] [Cited by in Crossref: 39] [Cited by in F6Publishing: 43] [Article Influence: 4.3] [Reference Citation Analysis]
20 Liu K, Lei XZ, Zhao LS, Tang H, Liu L, Feng P, Lei BJ. Tissue microarray for high-throughput analysis of gene expression profiles in hepatocellular carcinoma. World J Gastroenterol 2005; 11(9): 1369-1372 [PMID: 15761978 DOI: 10.3748/wjg.v11.i9.1369] [Cited by in CrossRef: 7] [Cited by in F6Publishing: 7] [Article Influence: 0.4] [Reference Citation Analysis]
21 Koh C, Heller T, Glenn JS. Pathogenesis of and New Therapies for Hepatitis D. Gastroenterology. 2019;156:461-476.e1. [PMID: 30342879 DOI: 10.1053/j.gastro.2018.09.058] [Cited by in Crossref: 33] [Cited by in F6Publishing: 28] [Article Influence: 8.3] [Reference Citation Analysis]
22 Lu JW, Yang WY, Tsai SM, Lin YM, Chang PH, Chen JR, Wang HD, Wu JL, Jin SL, Yuh CH. Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. PLoS One. 2013;8:e76951. [PMID: 24130815 DOI: 10.1371/journal.pone.0076951] [Cited by in Crossref: 39] [Cited by in F6Publishing: 37] [Article Influence: 4.3] [Reference Citation Analysis]
23 Liu YP, Yang XN, Jazag A, Pan JS, Hu TH, Liu JJ, Guleng B, Ren JL. HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. PLoS One. 2012;7:e36914. [PMID: 22615844 DOI: 10.1371/journal.pone.0036914] [Cited by in Crossref: 10] [Cited by in F6Publishing: 10] [Article Influence: 1.0] [Reference Citation Analysis]
24 Yu DY. Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein. Lab Anim Res 2020;36:6. [PMID: 32206612 DOI: 10.1186/s42826-020-00037-1] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
25 Hu L, Chen L, Li L, Sun H, Yang G, Chang Y, Tu Q, Wu M, Wang H. Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1. J Virol 2011;85:3214-28. [PMID: 21228225 DOI: 10.1128/JVI.01841-10] [Cited by in Crossref: 21] [Cited by in F6Publishing: 12] [Article Influence: 1.9] [Reference Citation Analysis]
26 You X, Liu F, Zhang T, Li Y, Ye L, Zhang X. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis. 2013;34:1644-1652. [PMID: 23471881 DOI: 10.1093/carcin/bgt089] [Cited by in Crossref: 58] [Cited by in F6Publishing: 63] [Article Influence: 6.4] [Reference Citation Analysis]
27 Zhang S, Sang X, Hou D, Chen J, Gu H, Zhang Y, Li J, Yang D, Zhu H, Yang X, Wang F, Zhang C, Chen X, Zen K, Zhang C, Hong Z. Plant-derived RNAi therapeutics: A strategic inhibitor of HBsAg. Biomaterials 2019;210:83-93. [DOI: 10.1016/j.biomaterials.2019.04.033] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 2.0] [Reference Citation Analysis]
28 Xu Y, Qi Y, Luo J, Yang J, Xie Q, Deng C, Su N, Wei W, Shi D, Xu F, Li X, Xu P. Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42. Int J Mol Sci 2017;18:E586. [PMID: 28282856 DOI: 10.3390/ijms18030586] [Cited by in Crossref: 8] [Cited by in F6Publishing: 12] [Article Influence: 1.6] [Reference Citation Analysis]
29 Wu L, Tang Z, Li Y. Experimental models of hepatocellular carcinoma: developments and evolution. J Cancer Res Clin Oncol 2009;135:969-81. [DOI: 10.1007/s00432-009-0591-7] [Cited by in Crossref: 24] [Cited by in F6Publishing: 28] [Article Influence: 1.8] [Reference Citation Analysis]
30 Ou DP, Tao YM, Chang ZG, Tang FQ, Yang LY. Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally. Dig Liver Dis. 2006;38:262-267. [PMID: 16461023 DOI: 10.1016/j.dld.2005.10.027] [Cited by in Crossref: 8] [Cited by in F6Publishing: 10] [Article Influence: 0.5] [Reference Citation Analysis]
31 Li C, Lin C, Cong X, Jiang Y. PDK1-WNK1 signaling is affected by HBx and involved in the viability and metastasis of hepatic cells. Oncol Lett 2018;15:5940-6. [PMID: 29563998 DOI: 10.3892/ol.2018.8001] [Cited by in Crossref: 3] [Cited by in F6Publishing: 6] [Article Influence: 0.8] [Reference Citation Analysis]
32 Elazar M, Glenn JS. Emerging concepts for the treatment of hepatitis delta. Curr Opin Virol 2017;24:55-9. [PMID: 28475945 DOI: 10.1016/j.coviro.2017.04.004] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 2.6] [Reference Citation Analysis]
33 Guan J, Chen XP, Zhu H, Luo SF, Cao B, Ding L. Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line. World J Gastroenterol 2004; 10(23): 3522-3527 [PMID: 15526378 DOI: 10.3748/wjg.v10.i23.3522] [Cited by in CrossRef: 26] [Cited by in F6Publishing: 24] [Article Influence: 1.4] [Reference Citation Analysis]
34 Naganuma H, Ishida H, Ogawa M, Sato T, Sageshima M, Suzuki K, Ohyama Y. Hepatocellular carcinoma in otherwise sonographically normal liver. J Clin Ultrasound 2019;47:325-30. [PMID: 30484875 DOI: 10.1002/jcu.22677] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.5] [Reference Citation Analysis]
35 Wang Y, Ren Y, Song Y, Xue Y, Zhang X, Cao S, Deng Z, Wu J, Chen L, Li G, Shi K, Chen Y, Ren H, Huang A, Tang K. MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1. CARCIN 2014;35:2127-33. [DOI: 10.1093/carcin/bgu128] [Cited by in Crossref: 17] [Cited by in F6Publishing: 17] [Article Influence: 2.1] [Reference Citation Analysis]
36 Liu Y, Lou G, Wu W, Shi Y, Zheng M, Chen Z. Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation. Virol J. 2013;10:168. [PMID: 23718853 DOI: 10.1186/1743] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
37 Liu Y, Lou G, Wu W, Shi Y, Zheng M, Chen Z. Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation. Virol J 2013;10:168. [PMID: 23718853 DOI: 10.1186/1743-422X-10-168] [Cited by in Crossref: 13] [Cited by in F6Publishing: 12] [Article Influence: 1.4] [Reference Citation Analysis]
38 Li J, Dai X, Zhang H, Zhang W, Sun S, Gao T, Kou Z, Yu H, Guo Y, Du L, Jiang S, Zhang J, Zhou Y. Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin. Oncotarget 2015;6:29196-208. [PMID: 26470691 DOI: 10.18632/oncotarget.5039] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.3] [Reference Citation Analysis]
39 Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Wang Y, Yang X, Ye L, Zhang X. Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology 2012;56:2051-9. [PMID: 22707013 DOI: 10.1002/hep.25899] [Cited by in Crossref: 125] [Cited by in F6Publishing: 118] [Article Influence: 12.5] [Reference Citation Analysis]
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41 Su JM, Lai XM, Lan KH, Li CP, Chao Y, Yen SH, Chang FY, Lee SD, Lee WP. X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter. Hepatology 2007;46:402-13. [PMID: 17559154 DOI: 10.1002/hep.21675] [Cited by in Crossref: 29] [Cited by in F6Publishing: 29] [Article Influence: 1.9] [Reference Citation Analysis]
42 Wei X, Tan C, Tang C, Ren G, Xiang T, Qiu Z, Liu R, Wu Z. Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma. Cell Signal. 2013;25:1037-1043. [PMID: 23376496 DOI: 10.1016/j.cellsig.2013.01.019] [Cited by in Crossref: 65] [Cited by in F6Publishing: 73] [Article Influence: 7.2] [Reference Citation Analysis]
43 Chiu SY, Chung HJ, Chen YT, Huang MS, Huang CC, Huang SF, Matsuura I. A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1. PLoS One 2019;14:e0208665. [PMID: 30870427 DOI: 10.1371/journal.pone.0208665] [Reference Citation Analysis]
44 Yang F, Yin Y, Wang F, Zhang L, Wang Y, Sun S. An altered pattern of liver apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression. J Proteome Res. 2010;9:134-143. [PMID: 19788185 DOI: 10.1021/pr900593r] [Cited by in Crossref: 20] [Cited by in F6Publishing: 26] [Article Influence: 1.7] [Reference Citation Analysis]
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48 Ng J, Wu J. Hepatitis B- and hepatitis C-related hepatocellular carcinomas in the United States: similarities and differences. Hepat Mon 2012;12:e7635. [PMID: 23233865 DOI: 10.5812/hepatmon.7635] [Cited by in Crossref: 32] [Cited by in F6Publishing: 31] [Article Influence: 3.2] [Reference Citation Analysis]
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50 Yang F, Yan S, He Y, Wang F, Song S, Guo Y, Zhou Q, Wang Y, Lin Z, Yang Y. Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. J Hepatol. 2008;48:12-19. [PMID: 18037187 DOI: 10.1016/j.jhep.2007.06.021] [Cited by in Crossref: 54] [Cited by in F6Publishing: 51] [Article Influence: 3.6] [Reference Citation Analysis]
51 Martin-Vilchez S, Lara-Pezzi E, Trapero-Marugán M, Moreno-Otero R, Sanz-Cameno P. The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection. Rev Med Virol 2011;21:315-29. [PMID: 21755567 DOI: 10.1002/rmv.699] [Cited by in Crossref: 24] [Cited by in F6Publishing: 24] [Article Influence: 2.2] [Reference Citation Analysis]
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53 Huang JF, Wang Y, Liu F, Liu Y, Zhao CX, Guo YJ, Sun SH. EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs. Oncotarget. 2016;7:21887-21899. [PMID: 26967394 DOI: 10.18632/oncotarget.7993] [Cited by in Crossref: 5] [Cited by in F6Publishing: 3] [Article Influence: 1.0] [Reference Citation Analysis]
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55 Ni Z, Lu J, Huang W, Khan H, Wu X, Huang D, Shi G, Niu Y, Huang H. Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma. PeerJ 2021;9:e12697. [PMID: 35036167 DOI: 10.7717/peerj.12697] [Reference Citation Analysis]
56 Li YT, Wu HL, Liu CJ. Molecular Mechanisms and Animal Models of HBV-Related Hepatocellular Carcinoma: With Emphasis on Metastatic Tumor Antigen 1. Int J Mol Sci 2021;22:9380. [PMID: 34502289 DOI: 10.3390/ijms22179380] [Reference Citation Analysis]
57 Du Y, Broering R, Li X, Zhang X, Liu J, Yang D, Lu M. In Vivo Mouse Models for Hepatitis B Virus Infection and Their Application. Front Immunol 2021;12:766534. [PMID: 34777385 DOI: 10.3389/fimmu.2021.766534] [Reference Citation Analysis]
58 Niu Y, Fan S, Luo Q, Chen L, Huang D, Chang W, Qin W, Shi G. Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis. J Clin Transl Hepatol 2021;9:466-76. [PMID: 34447675 DOI: 10.14218/JCTH.2021.00036] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
59 Chen X, Yamamoto M, Fujii K, Nagahama Y, Ooshio T, Xin B, Okada Y, Furukawa H, Nishikawa Y. Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions. Cancer Sci 2015;106:972-81. [PMID: 26011625 DOI: 10.1111/cas.12700] [Cited by in Crossref: 26] [Cited by in F6Publishing: 26] [Article Influence: 3.7] [Reference Citation Analysis]
60 Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, Li J, Sun C, Yang J, Yang Z, Yang X, Lu J, Xi JJ. Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. Nat Commun 2016;7:11012. [PMID: 26987776 DOI: 10.1038/ncomms11012] [Cited by in Crossref: 26] [Cited by in F6Publishing: 23] [Article Influence: 4.3] [Reference Citation Analysis]
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