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For: Downes TD, Jones SP, Klein HF, Wheldon MC, Atobe M, Bond PS, Firth JD, Chan NS, Waddelove L, Hubbard RE, Blakemore DC, De Fusco C, Roughley SD, Vidler LR, Whatton MA, Woolford AJ, Wrigley GL, O'Brien P. Design and Synthesis of 56 Shape-Diverse 3D Fragments. Chemistry 2020;26:8969-75. [PMID: 32315100 DOI: 10.1002/chem.202001123] [Cited by in Crossref: 12] [Cited by in F6Publishing: 7] [Article Influence: 6.0] [Reference Citation Analysis]
Number Citing Articles
1 St Denis JD, Hall RJ, Murray CW, Heightman TD, Rees DC. Fragment-based drug discovery: opportunities for organic synthesis. RSC Med Chem 2020;12:321-9. [PMID: 34041484 DOI: 10.1039/d0md00375a] [Cited by in Crossref: 6] [Cited by in F6Publishing: 1] [Article Influence: 3.0] [Reference Citation Analysis]
2 Caplin MJ, Foley DJ. Emergent synthetic methods for the modular advancement of sp3-rich fragments. Chem Sci 2021;12:4646-60. [PMID: 34168751 DOI: 10.1039/d1sc00161b] [Cited by in Crossref: 5] [Article Influence: 5.0] [Reference Citation Analysis]
3 Sedenkova KN, Andriasov KS, Eremenko MG, Grishin YK, Alferova VA, Baranova AA, Zefirov NA, Zefirova ON, Zarubaev VV, Gracheva YA, Milaeva ER, Averina EB. Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity. Molecules 2022;27:3546. [PMID: 35684482 DOI: 10.3390/molecules27113546] [Reference Citation Analysis]
4 Revillo Imbernon J, Jacquemard C, Bret G, Marcou G, Kellenberger E. Comprehensive analysis of commercial fragment libraries. RSC Med Chem . [DOI: 10.1039/d1md00363a] [Reference Citation Analysis]
5 Silvestri IP, Colbon PJJ. The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID: Topical Innovations. ACS Med Chem Lett 2021;12:1220-9. [PMID: 34413951 DOI: 10.1021/acsmedchemlett.1c00251] [Cited by in Crossref: 6] [Cited by in F6Publishing: 3] [Article Influence: 6.0] [Reference Citation Analysis]
6 Carbery A, Skyner R, von Delft F, Deane CM. Fragment Libraries Designed to Be Functionally Diverse Recover Protein Binding Information More Efficiently Than Standard Structurally Diverse Libraries. J Med Chem 2022. [PMID: 35960886 DOI: 10.1021/acs.jmedchem.2c01004] [Reference Citation Analysis]
7 Kwong A, Firth JD, Farmer TJ, O’brien P. Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine. Tetrahedron 2021;81:131899. [DOI: 10.1016/j.tet.2020.131899] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
8 Klein HF, Hamilton DJ, J. P. de Esch I, Wijtmans M, O'brien P. Escape from planarity in fragment-based drug discovery: a synthetic strategy analysis of synthetic 3D fragment libraries. Drug Discovery Today 2022. [DOI: 10.1016/j.drudis.2022.05.021] [Reference Citation Analysis]
9 Townley C, McMurray L, Marsden SP, Nelson A. A unified "top-down" approach for the synthesis of diverse lead-like molecular scaffolds. Bioorg Med Chem Lett 2022;:128631. [PMID: 35181466 DOI: 10.1016/j.bmcl.2022.128631] [Reference Citation Analysis]
10 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, Aimon A, Bennett JM, Neto JB, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs M, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, Jura N, Ashworth A, Irwin J, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I; QCRG Structural Biology Consortium., Johannes Gregor Matthias Rack. Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking. bioRxiv 2020:2020. [PMID: 33269349 DOI: 10.1101/2020.11.24.393405] [Cited by in Crossref: 7] [Cited by in F6Publishing: 3] [Article Influence: 3.5] [Reference Citation Analysis]
11 Choi A, Meijer AJHM, Silvestri IP, Coldham I. Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments. J Org Chem 2022. [PMID: 35699313 DOI: 10.1021/acs.joc.2c00862] [Reference Citation Analysis]
12 Hamilton DJ, Dekker T, Klein HF, Janssen GV, Wijtmans M, O'Brien P, de Esch IJP. Escape from planarity in fragment-based drug discovery: A physicochemical and 3D property analysis of synthetic 3D fragment libraries. Drug Discov Today Technol 2020;38:77-90. [PMID: 34895643 DOI: 10.1016/j.ddtec.2021.05.001] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
13 Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandão-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keserü GM, Klein HF, Martin MP, Noble MEM, O'Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA. Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nat Commun 2020;11:5047. [PMID: 33028810 DOI: 10.1038/s41467-020-18709-w] [Cited by in Crossref: 109] [Cited by in F6Publishing: 83] [Article Influence: 54.5] [Reference Citation Analysis]
14 de Esch IJP, Erlanson DA, Jahnke W, Johnson CN, Walsh L. Fragment-to-Lead Medicinal Chemistry Publications in 2020. J Med Chem 2021. [PMID: 34928151 DOI: 10.1021/acs.jmedchem.1c01803] [Reference Citation Analysis]
15 Chhabra S, Kumar S, Parkesh R. Chemical Space Exploration of DprE1 Inhibitors Using Chemoinformatics and Artificial Intelligence. ACS Omega 2021;6:14430-41. [PMID: 34124465 DOI: 10.1021/acsomega.1c01314] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
16 Fominova K, Diachuk T, Granat D, Savchuk T, Vilchynskyi V, Svitlychnyi O, Meliantsev V, Kovalchuk I, Litskan E, Levterov VV, Badlo VR, Vaskevych RI, Vaskevych AI, Bolbut AV, Semeno VV, Iminov R, Shvydenko K, Kuznetsova AS, Dmytriv YV, Vysochyn D, Ripenko V, Tolmachev AA, Pavlova O, Kuznietsova H, Pishel I, Borysko P, Mykhailiuk PK. Oxa-spirocycles: synthesis, properties and applications. Chem Sci 2021;12:11294-305. [PMID: 34667540 DOI: 10.1039/d1sc03615g] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
17 Wu H, Du C, Xu Y, Liu L, Zhou X, Ji Q. Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3′-quinolin]-2′-one derivatives as potential chitin synthase inhibitors and antifungal agents. European Journal of Medicinal Chemistry 2022;233:114208. [DOI: 10.1016/j.ejmech.2022.114208] [Reference Citation Analysis]
18 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I; QCRG Structural Biology Consortium. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv 2021;7:eabf8711. [PMID: 33853786 DOI: 10.1126/sciadv.abf8711] [Cited by in Crossref: 11] [Cited by in F6Publishing: 10] [Article Influence: 11.0] [Reference Citation Analysis]
19 Gomez-angel AR, Donald JR, Firth JD, De Fusco C, Ian Storer R, Cox DJ, O’brien P. Synthesis and functionalisation of a bifunctional normorphan 3D building block for medicinal chemistry. Tetrahedron 2021;83:131961. [DOI: 10.1016/j.tet.2021.131961] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 3.0] [Reference Citation Analysis]
20 López L, Cabal MP, Valdés C. Construction of NH-Unprotected Spiropyrrolidines and Spiroisoindolines by [4+1] Cyclizations of γ-Azidoboronic Acids with Cyclic N-Sulfonylhydrazones. Angew Chem Int Ed Engl 2021. [PMID: 34677906 DOI: 10.1002/anie.202113370] [Reference Citation Analysis]
21 Piticari A, Antermite D, Higham JI, Moore JH, Webster MP, Bull JA. Stereoselective Palladium‐Catalyzed C( sp3 )−H Mono‐Arylation of Piperidines and Tetrahydropyrans with a C(4) Directing Group. Adv Synth Catal 2022;364:1488-97. [DOI: 10.1002/adsc.202200030] [Reference Citation Analysis]