长链非编码RNA SNHG16在消化系统肿瘤中作用机制研究进展

表1 SNHG16在消化系统肿瘤中的功能作用

肿瘤类型	表达水平	致癌/抑癌基因	功能作用	miRNAs	目标基因	参考文献
GC	Up-regulated	Oncogene	Proliferation, migration, invasion, apoptosis	/	/	[7]
GC	Up-regulated	Oncogene	Proliferation, invasionability, apoptosis	miR-135a-5p	JAK2/STAT3	[8]
GC	Up-regulated	Oncogene	Mediating 5-fu resistance	miR-506-3p	PTBP1	[9]
GC	Up-regulated	Oncogene	EMT, invasion	/	DKK3	[10]
GC	Up-regulated	Oncogene	Proliferation, apoptosis, migration, invasion	/	P53, c-Myc	[11]
CRC	Up-regulated	Oncogene	Migration, apoptosis	/	ASCL2, ETS2, c-Myc	[13]
CRC	Up-regulated	Oncogene	Proliferation, migration	miR-200a-3p	/	[14]
Colon cancer	Up-regulated	Oncogene	Proliferation	miR-302a-3p	AKT	[15]
CRC	Up-regulated	Oncogene	Proliferation, migration, invasion, apoptosis	miR-132-3p	USP22	[16]
CRC	Up-regulated	Oncogene	Proliferation, apoptosis	miR-214-3p	ABCB1	[17]
CRC	Up-regulated	Oncogene	Proliferation, migration, invasion, EMT	miR-124-3p	MCP-1	[18]
CRC	Up-regulated	Oncogene	Proliferation, migration, invasion, EMT	miR-195-5p	YAP1/TEAD1	[19]
ESCC	Up-regulated	Oncogene	Proliferation, invasion, apoptosis	/	c-myc, cyclin	[21]
ESCC	Up-regulated	Oncogene	Proliferation, migration, apoptosis, EMT	miR-140-5p	ZEB1	[22]
EC	Up-regulated	Oncogene	Proliferation	miR-802	PTCH1	[23]
ESCC	Up-regulated	Oncogene	Proliferation, migration	/	EIF4A3/RhoU	[24]
PC	Up-regulated	Oncogene	Proliferation, migration, invasion, apoptosis	miR-302b-3p	SLC2A4	[26]
PC	Up-regulated	Oncogene	Proliferation, migration, invasion, lipogenesis	miR-195	SREBP2	[27]
CCA	Up-regulated	Oncogene	Proliferation, apoptosis	miR-146a-5p	GATA6	[29]
HCC	Up-regulated	Oncogene	Proliferation, migration, invasion	/	/	[31]
HCC	Up-regulated	Oncogene	Proliferation, migration, invasion, apoptosis	miR-17-5p	P62	[32]
HCC	Up-regulated	Oncogene	Invasiveness, proliferation	/	/	[33]
HCC	Up-regulated	Oncogene	Proliferation, migration, invasion	miR-186	/	[34]
HCC	Up-regulated	Oncogene	Proliferation, invasion tumorigenesis	miR-195	/	[35]
HCC	Up-regulated	Oncogene	Proliferation, migration, invasion, apoptosis and EMT	miR-4500	STAT3	[36]
HCC	Up-regulated	Oncogene	Proliferation	miR-302a-3p	FGF19	[37]
HCC	Up-regulated	Oncogene	Metastasis, EMT	miR-605-3p	TRAF6、NF-κB	[38]
HCC	Up-regulated	Oncogene	Viability, apoptosis	miR-23b-3p	EGR1	[39]
HCC	Up-regulated	Oncogene	Proliferation, migration, invasion, EMT, apoptosis	let-7b-5p	CDC25B、HMGA2	[41]
HCC	Up-regulated	Oncogene	Angiogenesis	miR-4500	GALNT1、PI3K/Akt/mTOR	[43]
HCC	Up-regulated	Oncogene	Metastasis	miR 942 3p	MMP9	[44]
HCC	Down-regulated	Tumor suppressor	Proliferation, chemoresistance, tumorigenicity	hsa-miR-93	/	[45]

SNHG16: 小核仁RNA宿主基因16; EMT: 上皮间质转换; DKK3: Dickkopf WNT信号通路抑制因子3; TEAD1: YAP1结合TEA结构域转录因子1; GC:胃癌; CRC: 结直肠癌; ESCC: 食管鳞癌; PC: 胰腺癌; HCC: 肝细胞癌; CAA: 胆管癌.

表2 SNHG16在消化系统肿瘤中的临床病理特征

肿瘤类型	临床特征	参考文献
GC	Invasion depth, lymph node metastasis, TNM stage, histological differentiation	[7]
GC	Tumor size, TNM stage, poor survival	[8]
GC	Invasion depth	[11]
CRC	TNM stage	[13]
CRC	Metastasis, lymph node	[14]
CRC	LV1, PNI, TNM stage, lymph node, metastasis, distant metastasis, poor prognosis	[19]
ESCC	Tumor stage, lymph nodes metastasis, clinical stage, poor survival, poor prognosis	[21]
ESCC	Tumour differentiation, T stage	[24]
PC	Poor prognosis	[26]
PC	Gemcitabine resistance	[28]
HCC	Tumor size, AFP level, PVTT, metastasis, poor survival, sorafenib resistance	[31]
HCC	Multiple tumors, macrovascular invasion, poor prognosis	[32]
HCC	Serum AFP level, poor prognosis	[33]
HCC	Tumor size, TNM stage, ALT level, HBV DNA level	[34]
HCC	Tumor size, lymph node status, TNM stage and poor prognosis	[36]
HCC	Poor prognosis	[37]
HCC	Tumour diameter, tumour thrombus, tumour satellites, poor prognosis	[38]
HCC	Sorafenib resistance	[39]
HCC	Tumor size, TNM stage, vascular invasion, sorafenib resistance	[40]
HCC	Poor prognosis	[44]

SNHG16: 小核仁RNA宿主基因16; GC: 胃癌; CRC: 结直肠癌; ESCC: 食管鳞癌; PC: 胰腺癌; HCC: 肝细胞癌; LVI: 淋巴血管侵袭; PNI: 神经周围侵犯; PVTT: 门静脉肿瘤血栓; AFP: 甲胎蛋白; TNM: 肿瘤, 淋巴结, 转移; HBV: 乙型肝炎病毒; ALT: 丙氨酸转氨酶.