Copyright
©The Author(s) 2021.
世界华人消化杂志. 2021-11-08; 29(21): 1237-1247
在线出版 2021-11-08. doi: 10.11569/wcjd.v29.i21.1237
在线出版 2021-11-08. doi: 10.11569/wcjd.v29.i21.1237
耐药相关机制 | 肿瘤 | circRNAs | 化疗药物 | 参考文献 |
影响细胞凋亡 | 肝癌 | circRNA-SORE、circFN1、circFOXM1 | 索拉非尼 | [22,41-43] |
circ_0031242、circRNA_101505 | 铂类 | [46,48] | ||
胃癌 | circVAPA、circDONSON、circCCDC66、circFN1、hsa_circ_0081143、circPVT1、circ_0001546 | 铂类 | [56-62,68] | |
circRACGAP1 | 阿帕替尼 | [34] | ||
circMTHFD2 | 培美曲塞 | [70] | ||
circHECTD1 | Diosbulbin-B | [71] | ||
结直肠癌 | circ_0032833、circDDX17 | 5-氟尿嘧啶 | [77,78] | |
circ_0032833、hsa_circ_0079662、circ_0071589 | 铂类 | [77,80,81] | ||
circCSPP1 | 阿霉素 | [82] | ||
食管癌 | circ_0006168 | 紫杉醇 | [87] | |
circPSMC3 | 吉非替尼 | [88] | ||
促进药物转运 | 肝癌 | circFBXO11 | 奥沙利铂 | [25] |
circFoxo3 | 阿霉素 | [50] | ||
circPTGR1 | 5-氟尿嘧啶 | [51] | ||
胃癌 | circMTHFD2 | 培美曲塞 | [70] | |
结直肠癌 | circ_0007031 | 5-氟尿嘧啶 | [75] | |
hsa_circ_0005963 | 铂类 | [24] | ||
促进DNA修复 | 胃癌 | circAKT3 | 铂类 | [27] |
促进上皮-间充质转化(EMT) | 肝癌 | circFoxo3、circ_0003998 | 阿霉素 | [50,52] |
胃癌 | circPVT1 | 紫杉醇 | [29] | |
结直肠癌 | circDDX17 | 5-氟尿嘧啶 | [78] | |
胰腺癌 | circHIPK3 | 吉西他滨 | [91] | |
调控肿瘤干细胞特性(CSCs) | 胃癌 | circFAM73A | 铂类 | [32] |
结直肠癌 | circ_001680 | 伊立替康 | [83] | |
影响自噬 | 肝癌 | circARNT2 | 铂类 | [45] |
胃癌 | circPVT1、circ_0032821、circCUL2、circMCTP2 | 铂类 | [61,64,66,67] | |
circRACGAP1 | 阿帕替尼 | [34] |
癌症 | circRNA | 表达 | 促进/抑制耐药 | 机制 | 细胞系 | 化疗药物 | 参考文献 |
肝癌 | circRNA-SORE | ↑ | 促进 | YBX1 | HepG2、LM3和SKHep1 | 索拉非尼 | [41] |
circRNA-SORE | ↑ | 促进 | miR-103a-2-5p和miR-660-3p/Wnt/β-catenin | HepG2、LM3和SKHep1 | 索拉非尼 | [22] | |
circFN1 | ↑ | 促进 | miR-1205/E2F1 | Huh7和HepG2 | 索拉非尼 | [42] | |
circFOXM1 | ↑ | 促进 | miR-1324/MECP2 | HepG2 和 Huh7 | 索拉非尼 | [43] | |
circARNT2 | ↑ | 促进 | miR-155-5p/PDK1 | Hep3B和Huh7 | 顺铂 | [45] | |
circ_0031242 | ↑ | 促进 | miR-924/POU3F2 | HuH7和SNU387 | 顺铂 | [46] | |
circRNA_102272 | ↑ | 促进 | MiR-326/RUNX2 | HepG2和HuH7 | 顺铂 | [47] | |
circFBXO11 | ↑ | 促进 | miR-605/FOXO3/ABCB1 | HepG2 | 奥沙利铂 | [25] | |
circRNA_101505 | ↓ | 抑制 | miR-103/NOR1 | Hep3B和Huh7 | 顺铂 | [48] | |
circ_0003418 | ↓ | 抑制 | Wnt/β-Catenin | Hep3B和Huh7 | 顺铂 | [49] | |
circFoxo3 | ↑ | 促进 | miR-199a-5p/ABCC1 | SKHEP-1和HepG2 | 阿霉素 | [50] | |
circular PTGR1 | ↑ | 促进 | miR-129-5p/ABCC1 | Hep3B和Huh7 | 5-氟尿嘧啶 | [51] | |
circ_0003998 | ↑ | 促进 | miR-218-5p/EIF5A2 | Huh7和HCCLM3 | 阿霉素 | [52] | |
胃癌 | circVAPA | ↑ | 促进 | miR-125b-5p/STAT3 | SGC7901和HGC27 | 顺铂 | [56] |
circAKT3 | ↑ | 促进 | miR-198/PIK3R1 | SGC7901 | 顺铂 | [27] | |
circFAM73A | ↑ | 促进 | miR-490-3p /HMGA2 | BGC823和SGC7901 | 顺铂 | [32] | |
circDONSON | ↑ | 促进 | miR-802/BMI1 | AGS和HGC-27 | 顺铂 | [57] | |
circCCDC66 | ↑ | 促进 | miR-618 /BCL2 | BGC823和SGC7901 | 顺铂 | [58] | |
circFN1 | ↑ | 促进 | miR-182-5p | SGC7901 | 顺铂 | [59] | |
hsa_circ_0081143 | ↑ | 促进 | miR-646/CDK6 | SGC7901和MGC803 | 顺铂 | [60] | |
circ-PVT1 | ↑ | 促进 | miR-30a-5p/YAP1 | HGC-27和AGS | 顺铂 | [61] | |
circPVT1 | ↑ | 促进 | miR-152-3p/HDGF/PI3K/AKT | AGS和HGC-27 | 顺铂 | [62] | |
circ_0026359 | ↑ | 促进 | miR-1200/POLD4 | SGC-7901和MKN-45 | 顺铂 | [63] | |
circ_0032821 | ↑ | 促进 | miR-515-5p/SOX9 | HGC-27和AGS | 奥沙利铂 | [64] | |
hsa_circ_0000144 | ↑ | 促进 | miR-502-5p/ADAM9 | AGS和MKN45 | 奥沙利铂 | [65] | |
circCUL2 | ↓ | 抑制 | miR-142-3p/ROCK2 | AGS和SGC-7901 | 顺铂 | [66] | |
circMCTP2 | ↓ | 抑制 | miR-99a-5p/MTMR3 | BGC823和SGC7901 | 顺铂 | [67] | |
hsa_circ_0001546 | ↓ | 抑制 | miR-421/ATM/Chk2/p53 | HGC-27 | 奥沙利铂 | [68] | |
circRACGAP1 | ↑ | 促进 | miR-3657/ATG7 | BGC-823和HGC-27 | 阿帕替尼 | [34] | |
circ-PVT1 | ↑ | 促进 | miR-124-3p/ZEB1 | MGC-803和AGS | 紫杉醇 | [29] | |
circNRIP1 | ↑ | 促进 | miR-138-5p/HIF-1α | SGC-7901和 BGC-823 | 5-氟尿嘧啶 | [69] | |
circMTHFD2 | ↑ | 促进 | miR-124/FDZ5/MDR-1 | MGC-803 | 培美曲塞 | [70] | |
circHECTD1 | ↑ | 促进 | miR-137/PBX3 | AGS和HGC-27 | Diosbulbin-B | [71] | |
结直肠癌 | circ_0007031 | ↑ | 促进 | miR-133b/ABCC5 | HCT116和SW480 | 5-氟尿嘧啶 | [75] |
circ-PRKDC | ↑ | 促进 | miR-375/FOXM1/Wnt/β-catenin | SW620和SW480 | 5-氟尿嘧啶 | [76] | |
circ_0032833 | ↑ | 促进 | miR-125-5p/MSI1 | HCT116 | 5-氟尿嘧啶和奥沙利铂 | [77] | |
circDDX17 | ↓ | 抑制 | miR-31-5p/KANK1 | HCT116和SW480 | 5-氟尿嘧啶 | [78] | |
hsa_circ_0005963 | ↑ | 促进 | miR-122/PKM2 | HCT116和SW480 | 奥沙利铂 | [24] | |
circ-CCDC66 | ↑ | 促进 | -- | HCT116和HT-2 | 奥沙利铂 | [79] | |
hsa_circ_0079662 | ↑ | 促进 | miR-324-5p/TNF-α | HCT116 | 奥沙利铂 | [80] | |
circ_0071589 | ↑ | 促进 | MiR-526b-3p/KLF12 | HCT116和LOVO | 顺铂 | [81] | |
circCSPP1 | ↑ | 促进 | miR-944/FZD7 | LoVo和HCT116 | 阿霉素 | [82] | |
hsa_circ_001680 | ↑ | 促进 | miR-340/BMI1 | SW480和HCT116 | 伊立替康 | [83] | |
食管癌 | circ_0006168 | ↑ | 促进 | miR-194-5p/JMJD1C | ECA109和KYSE150 | 紫杉醇 | [87] |
circPSMC3 | ↓ | 抑制 | miR-10a-5p/PTEN | TE1和KYSE450 | 吉非替尼 | [88] | |
胰腺癌 | circHIPK3 | ↑ | 促进 | miR-330-5p/RASSF1 | PANC-1和SW-1990 | 吉西他滨 | [91] |
引文著录: 林洁纯, 朱南星, 吴灵飞. circRNAs在消化系肿瘤化疗耐药中的研究进展. 世界华人消化杂志 2021; 29(21): 1237-1247