血清胃蛋白酶原、胃泌素17和糖链抗原CA72-4、CA199、CA125检测在胃癌筛查中的应用

表1 都各组受试者各项指标比较 (n = 90)

分组	PG (ng/mL)	CAS17 (ng/mL)	CA724 (ng/mL)	CA199 (U/mL)	CA125 (ng/mL)
胃癌组	29.45 ± 12.13	69.01 ± 14.23	2.25 ± 1.54	129.35 ± 62.23	89.26 ± 12.73
胃部良性疾病组	58.31 ± 17.08a	78.45 ± 17.67a	11.21 ± 4.52a	29.61 ± 9.43a	41.85 ± 10.33a
正常对照组	69.45 ± 16.23ac	79.65 ± 16.33ac	39.75 ± 6.05ac	10.95 ± 4.26ac	31.07 ± 11.80ac

^aP<0.05, 与胃癌组相比较;

^cP<0.05, 与胃部良性病变组相比较. PG: 胃蛋白酶原; CAS17: 胃泌素17; CA724: 糖链抗原724; CA199: 糖链抗原199; CA125: 糖链抗原125.

表2 胃癌组受试者TNM不同分期各指标比较

检测物	Ⅰ-Ⅱ期 (n = 32)	Ⅲ期 (n = 29)	Ⅳ期 (n = 29)
PG (ng/mL)	41.13 ± 12.21	29.12 ± 11.02a	23 ± 10.06ac
CAS17 (ng/mL)	81.25 ± 13.71	61.13 ± 10.68a	52.08 ± 12.36ac
CA724 (ng/mL)	13.16 ± 1.28	27.39 ± 2.21a	91.50 ± 2.24ac
CA199 (U/mL)	43.23 ± 8.90	61.03 ± 9.36a	144.73 ± 18.01ac
CA125 (ng/mL)	69.33 ± 14.81	72.63 ± 10.70a	91.79 ± 19.01ac

^aP<0.05, 与Ⅰ-Ⅱ期相比较;

^cP<0.05, 表示与Ⅲ期相比较. PG: 胃蛋白酶原; CAS17: 胃泌素17; CA724: 糖链抗原724; CA199: 糖链抗原199; CA125: 糖链抗原125.

表3 各检测指标单独检测与联合检测灵敏度与特异性比较

检测物	灵敏度 (%)	特异度 (%)
PG (ng/mL)	28.96	93.01
CAS17 (ng/mL)	60.54	88.97
CA724 (ng/mL)	54.38	91.31
CA199 (U/mL)	68.02	88.99
CA125 (ng/mL)	60.21	85.83
PG+CAS17+CA724+CA199+CA125	78.31	98.51

PG: 胃蛋白酶原; CAS17: 胃泌素17; CA724: 糖链抗原724; CA199: 糖链抗原199; CA125: 糖链抗原125.