慢性乙型肝炎患者肝组织Toll样受体3、4表达及其临床意义

表1 不同肝组织炎症活动度分级(G)与TLR3表达评级情况 n (%)

组别	n	TLR3表达评级				秩均值
		-	+	++	+++
G0	24	6 (0.25)	6 (0.25)	12 (0.5)	0 (0)	2.04
G1	72	6 (0.08)	42 (0.58)	12 (0.17)	12 (0.17)	3.54
G2	42	0 (0)	12 (0.28)	18 (0.44)	12 (0.28)	3.04
G3	18	0 (0)	0 (0)	6 (0.33)	12 (0.67)	1.38
G4	0	0 (0)	0 (0)	0 (0)	0 (0)	0

表2 组间t检验结果

组别	G1 vs G2	G1 vs G3	G2 vs G3	G0 vs G1	G0 vs G2	G0 vs G3
t值	3.602	4.532	5.745	-4.815	-4.690	1.483
P值	0.004	0.001	0.000	0.001	0.001	0.166

表3 肝纤维化程度分级(S)与TLR3表达评级情况 n (%)

组别	n	TLR3表达评级				秩均值
		-	+	++	+++
S0	12	0 (0)	12 (1)	0 (0)	0 (0)	1.00
S1	60	6 (0.1)	30 (0.5)	18 (0.3)	6 (0.2)	3.75
S2	54	6 (0.11)	18 (0.33)	12 (0.23)	18 (0.33)	4.50
S3	18	0 (0)	0 (0)	6 (0.33)	12 (0.67)	3.25
S4	12	0 (0)	0 (0)	6 (0.5)	6 (0.5)	2.50

表4 肝脏炎症活动度分级(G)与TLR4表达评级情况 n (%)

组别	n	TLR4表达评级				秩均值
		-	+	++	+++
G0	24	6 (0.25)	6 (0.25)	12 (0.5)	0 (0)	2.25
G1	72	6 (0.09)	18 (0.25)	24 (0.33)	24 (0.33)	2.50
G2	42	0 (0)	6 (0.14)	18 (0.43)	18 (0.43)	1.38
G3	18	0 (0)	0 (0)	6 (0.33)	12 (0.67)	3.88
G4	0	0 (0)	0 (0)	0 (0)	0 (0)	0

表5 组间t检验结果

组别	G1 vs G2	G1 vs G3	G2 vs G3	G0 vs G1	G0 vs G2	G0 vs G3
t值	5.000	4.700	2.449	-2.449	-0.878	0.333
P值	0.015	0.018	0.092	0.092	0.444	0.761

表6 肝纤维化程度分级(S)与TLR6表达评级情况 n (%)

组别	n	TLR4表达评级				秩均值
		-	+	++	+++
S0	12	6 (0.5)	0 (0)	6 (0.5)	0 (0)	1.50
S1	60	6 (0.1)	18 (0.3)	18 (0.3)	18 (0.3)	4.25
S2	54	0 (0)	12 (0.22)	18 (0.33)	24 (0.45)	4.75
S3	30	0 (0)	0 (0)	6 (0.3)	12 (0.7)	2.50
S4	22	0 (0)	0 (0)	6 (0.5)	6 (0.5)	2.00