外泌体在消化系统肿瘤诊断中的应用

表1 消化系统肿瘤相关的外泌体标志物

肿瘤类型	标志物类型	外泌体标志物
胰腺癌	蛋白质	GPC1, CD44v6, Tspan8, EpCAM, CD104, MIF[20,21,38]
	核酸	miR-18a, miR-20a, miR-21, miR-24, miR-25, miR-26, miR-99a, miR-155, miR-185, miR-191, miR-196a, miR-210, miR-1290, miR-1246, miR-3976, miR-4306 miR-4644[21,39-43]
结直肠癌	蛋白质	CD9, CD44, D62L, CD97, EpCAM, CDH 17, CLDN7, HSP70, CD147[24-26,44,45]
	核酸	Let-7, miR-10b, miR-15b, miR-17, mir-19a, mir-19b, miR-21, mir-23a, miR-29a, mir-92a, miR-142-3p, miR-195, mir-320a, miR-331, miR-332, miR-335, miR-339-3p, miR-375, miR-532, miR-532-3p, miR-652, miR-4437, ΔNp73[27,39,46-52]
胃癌	蛋白质	CD97, Cbl-b, Cbl-c[29-31]
	核酸	Let-7a, miR-17-5p, miR-21, miR-106a, miR-106b, miR-214, miR-218, miR-221, miR-222, miR-223, LINC00152[28,32,46,53-55]
肝癌	蛋白质	MET, integrin αvβ5, S100A4, CAV1, CAV2[33,56]
	核酸	miR-9, miR-10b, miR-18a, miR-19a, miR-21, miR-22, miR-25, miR-101, miR-106b, miR-107, miR-122, miR-124, miR125a-5p, miR-125b, miR129-5p, miR-195, miRNA-200a, miR-203, miR-210, miR-216a, miR217, miR-221, miR-222, miR-320a, miR-335, miR-370, miR-486-5p, miR-718, H19, HOTAIR, MALAT1[34,35,46,57-60]
其他消化系统肿瘤	蛋白质	PABP1[37]
	核酸	Let-7c, miR-18a, miR-21, miR-145, miR-155, miR-183, miR-184, miR-223-5p, miR-375, miR-200c, miR-483-5p[36,61-64]