血浆miR-210联合血清肿瘤标志物对胰腺癌的诊断价值

表1 血浆miR-210水平与胰腺癌患者临床特征的关系

临床特征	数值	miR-210
		r值	P值
性别		-0.051	0.697
年龄(岁)	57.87±12.32	-0.024a	0.858
CA199(U/mL)	142.82±198.91	-0.097a	0.460
CA242(U/mL)	45.77±160.5	0.013a	0.924
CEA(ng/mL)	3.46±5.19	0.044a	0.737
肿瘤最大直径(cm)	3.91±1.88	-0.004a	0.977
T stage		-0.047	0.722
N stage		-0.086	0.516
M stage		0.093	0.478
临床分期		0.205	0.116

^a为Pearson相关分析, 其余为Spearman秩相关分析. CA199: 糖链抗原199; CEA: 癌胚抗原

表2 血浆miR-210、CA199、CA242、CEA及联合在各组间的诊断效能

分组	敏感性(%)	特异性(%)	准确性(%)	LR+	LR-
胰腺癌组 vs 正常组
miR-210	96.7	50.0	90.0	1.93	0.07
CA199	91.7	30.0	82.9	1.31	0.28
CA242	98.3	10.0	85.7	1.09	0.17
CEA	100.0	0.0	85.7	--	--
CA199+CA242+CEA	93.3	30.0	84.3	1.33	0.22
miR-210+CA199	96.7	70.0	92.9	3.22	0.05
miR-210+CA199+CA242+CEA	96.7	70.0	92.9	3.22	0.05
胰腺癌组 vs 慢性胰腺炎组
miR-210	95.0	25.0	77.5	1.14	0.22
CA199	81.7	80.0	81.3	4.08	0.23
CA242	85.0	30.0	71.3	1.21	0.50
CEA	100.0	0.0	75.0	--	--
CA199+CA242+CEA	81.7	75.0	80.0	3.27	0.24
miR-210+CA199	90.0	85.0	88.8	6.00	0.12
miR-210+CA199+CA242+CEA	90.0	85.0	88.8	6.00	0.12
胰腺癌组 vs 慢性胰腺炎组+正常组
miR-210	86.7	40.0	71.1	1.44	0.33
CA199	78.3	93.3	83.3	11.75	0.23
CA242	76.7	83.3	78.9	4.60	0.28
CEA	98.3	10.0	68.9	1.09	0.17
CA199+CA242+CEA	80.0	93.3	84.4	12.00	0.21
miR-210+CA199	88.3	90.0	88.9	8.83	0.13
miR-210+CA199+CA242+CEA	86.7	90.0	87.8	8.67	0.15

CA199: 糖链抗原199; CEA: 癌胚抗原.