P162抑制Hedgehog信号转录因子Gli-1增强食管癌Eca109细胞的放射敏感性

表1 不同剂量的X线对Eca109、Eca109R细胞的增殖抑制率(CCK8法) (mean±SD, n = 6, %)

照射剂量(Gy)	IR
	24 h		48 h		72 h
	Eca109	Eca109R	Eca109	Eca109R	Eca109	Eca109R
2	10.70±1.08	3.91±1.44	19.35±1.45	6.65±1.19	31.79±1.25	7.51±1.00
4	12.65±1.09	9.53±1.17	36.11±1.47	11.81±1.14	47.94±0.93	13.64±1.17
6	21.23±1.55	13.73±1.41	46.98±1.32	21.73±1.34	51.72±1.32	23.68±1.12
8	43.52±1.07	31.64±1.41	56.93±1.20	32.84±1.52	71.95±1.36	38.35±1.11

IR: 抑制率.

表2 P162联合放疗对Eca109R、Eca109细胞早晚期凋亡率(%)

照射剂量(Gy)	分组	早期	晚期
0	Eca109	0.18	0.06
	Eca109R	0.12	0.02
	Eca109+P162	10.41	6.11
	Eca109R+P162	9.13	4.81
6	Eca109	5.39	1.71
	Eca109R	4.46	1.96
	Eca109+P162	26.36	18.08
	Eca109R+P162	20.62	4.84