溃疡性结肠炎与克罗恩病基因谱表达的差异

表1 溃疡性结肠炎、克罗恩病和正常细胞差异表达基因比较

分组	UC vs Normal	CD vs Normal	UC vs CD
UC vs Normal	3532	1907	564
CD vs Normal	1907	3035	327
UC vs CD	564	327	1232

UC: 溃疡性结肠炎; CD: 克罗恩病; Normal: 正常细胞.

表2 差异表达基因GO聚类分析

GO term	P值
Componont Compartment	0.005
Extracellular region	0.005
Cell fraction	0.005
Membrane fraction	0.005
Isoluble fraction	0.005
Extracellular space	0.005
Molecular function
Antigen binding	0.005
Cell surface binding	0.005
GDP binding	0.005
Eukaryotic cell surface binding	0.005
Nerve growth factor binding	0.005
Biological process
Positive regulation of cell differentiation	1.05×10-5
Positive regulation of developmental process	8.02×10-5
Neurogenesis	0.00013
Cell development	0.000162
Regulation of gastrulation	0.000162

表3 溃疡性结肠炎与克罗恩病不同的生物学通路

Term	P值
hsa05200: Pathways in cancer	5.71×10-6
hsa00100: Steroid biosynthesis	5.76×10-5
hsa04640: Hematopoietic cell lineage	7.73×10-5
hsa04662: B cell receptor signaling pathway	1.14×10-4
hsa04060: Cytokine-cytokine receptor interaction	0.002985
hsa04960: Aldosterone-regulated sodium reabsorption	0.003344
hsa04514: Cell adhesion molecules(CAMs)	0.004324
hsa05220: Chronic myeloid leukemia	0.007849
hsa05210: Colorectal cancer	0.009148
hsa04512: ECM-receptor interaction	0.009148