术前放化疗与单纯手术治疗可切除食管癌的Meta分析

表1 文献检索结果概述和纳入研究的一般特征

第一作者	发表年份	国家	放疗方案	化疗方案	放化疗顺序	病理类型	临床分期	分组	人数(n)	男/女(n)	中位年龄(yr)	中位生存期(mo)	中位随访期(mo)	Jadad评分[4]
Nygaard等[5]	1992	Norway	35 Gy, 1.75 Gy per fraction over 4 wk	Two cycles: cisplatin 20 mg/m2 d1-5; bleomycin 5 mg/m2 1-5 d	Sequential	SCC	T1 or T2, Nx, M0	CRTS	47	33/14	60.1	7	18	2
								SA	41	31/10	61.4	7
Apinop等[6]	1994	Thailand	40 Gy, 2 Gy per fraction over 4 wk	Two cycles: cisplatin 100 mg/m2 1 d; fluorouracil 1000 mg/m2 1-4 d	Concurrent	SCC	IIb(11); III(57)	CRTS	35	28/7	59.6	9.7	12	1
								SA	34	26/8	59.8	7.4
Le Prise等[7]	1994	France	40 Gy, 20 Gy in 10 fractions over 12 d	Two cycles: cisplatin 100 mg/m2 d1, 21; fluorouracil 600 mg/m2 2-5 d, 22-25 d	Sequential	SCC	I(23); II(63)	CRTS	41	80/6	56	10.2	16	2
								SA	45		59	11
Walsh等[8]	1996	Ireland	40 Gy in 15 fractions over 3 wk	Two cycles: cisplatin 75 mg/m2 1 d; fluorouracil 15 mg/kg 1-5 d	Concurrent	AC	not distant metastases	CRTS	58	39/19	65	16	10	2
								SA	55	44/11	65	11
Bosset等[9]	1997	France	37 Gy, 3.7 Gy per fraction over 2 wk	Two cycles: cisplatin 80 mg/m2 0-2 d	Sequential	SCC	T1N0(49); T2N0(92); T3N0(76); T1N1 or T2N1(65)	CRTS	143	129/14	56.7	18.6	55.2	3
								SA	139	134/5	56.6	18.6
Urba等[10]	2001	USA	45 Gy; 1.5 Gy per fraction over 3 wk	Two cycles: cisplatin 20 mg/m2 1-5 d; fluorouracil 300 mg/m2 1-21 d; vinblastine 1 mg/m2 1-4 d	Concurrent	SCC(25%); AC(75%)	not distant metastases	CRTS	50	42/8	62	16.9	98.4	2
								SA	50	43/7	64	17.6
安丰山等[11]	2003	China	36 Gy, 1.2 Gy per fraction over 17 d	First cycle: 5-fluorouracil 1 mg/m2, 5-6 h, 1-5 d; cisplatin 25 mg/m2.	Sequential	SCC	II, III	CRTS	48	31/17	58.4	42	34.12	3
								SA	50	47/3	63	27.3
第一作者	发表 年份	国家	放疗方案	化疗方案	放化疗顺序	病理类型	临床分期	分组	人数(n)	男/女 (n)	中位年 龄(yr)	中位生 存期(mo)	中位随 访期(mo)	Jadad 评分[4]
Nygaard等[5]	1992	Norway	35 Gy, 1.75 Gy per fraction over 4 wk	Two cycles: cisplatin 20 mg/m2 d1-5; bleomycin 5 mg/m2 1-5 d	Sequential	SCC	T1 or T2, Nx, M0	CRTS	47	33/14	60.1	7	18	2
								SA	41	31/10	61.4	7
Apinop等[6]	1994	Thailand	40 Gy, 2 Gy per fraction over 4 wk	Two cycles: cisplatin 100 mg/m2 1 d; fluorouracil 1000 mg/m2 1-4 d	Concurrent	SCC	IIb(11); III(57)	CRTS	35	28/7	59.6	9.7	12	1
								SA	34	26/8	59.8	7.4
Le Prise等[7]	1994	France	40 Gy, 20 Gy in 10 fractions over 12 d	Two cycles: cisplatin 100 mg/m2 d1, 21; fluorouracil 600 mg/m2 2-5 d, 22-25 d	Sequential	SCC	I(23); II(63)	CRTS	41	80/6	56	10.2	16	2
								SA	45		59	11
Walsh等[8]	1996	Ireland	40 Gy in 15 fractions over 3 wk	Two cycles: cisplatin 75 mg/m2 1 d; fluorouracil 15 mg/kg 1-5 d	Concurrent	AC	not distant metastases	CRTS	58	39/19	65	16	10	2
								SA	55	44/11	65	11
Bosset等[9]	1997	France	37 Gy, 3.7 Gy per fraction over 2 wk	Two cycles: cisplatin 80 mg/m2 0-2 d	Sequential	SCC	T1N0(49); T2N0(92); T3N0(76); T1N1 or T2N1(65)	CRTS	143	129/14	56.7	18.6	55.2	3
								SA	139	134/5	56.6	18.6
Urba等[10]	2001	USA	45 Gy; 1.5 Gy per fraction over 3 wk	Two cycles: cisplatin 20 mg/m2 1-5 d; fluorouracil 300 mg/m2 1-21 d; vinblastine 1 mg/m2 1-4 d	Concurrent	SCC(25%); AC(75%)	not distant metastases	CRTS	50	42/8	62	16.9	98.4	2
								SA	50	43/7	64	17.6
安丰山等[11]	2003	China	36 Gy, 1.2 Gy per fraction over 17 d	First cycle: 5-fluorouracil 1 mg/m2, 5-6 h, 1-5 d; cisplatin 25 mg/m2.	Sequential	SCC	II, III	CRTS	48	31/17	58.4	42	34.12	3
				Second cycle: 5-fluoro- uracil 0.5 g/m2, 21-25 d; cisplatin 25 mg/m2, 22-25 d				SA	49	30/19	57.6	28
Lee等[12]	2004	Korea	45.6 Gy, 1.2 Gy per fraction over 28 d	Two cycles: cisplatin 60 mg/m2 d1; fluorouracil 1000 mg/m2 3-5 d	Concurrent	SCC	IIA(36); IIB(22); III(43); N0(36); N1(65)	CRTS	51	46/5	63	28.2	25	2
Burmeister 等[13]	2005	Australia	35 Gy in 15 fractions over 3 wk	One cycles: cisplatin 80 mg/m2 d1; fluorouracil 800 mg/m2 1-4 d	Concurrent	SCC(37%); AC(62%)	T1-3, N0-1	CRTS	128	106/22	61	22.2	65	3
								SA	128	100/28	62	19.3
Natsugoe 等[14]	2006	Japan	40 Gy, 2 Gy per fraction over 4 wk	cisplatin 7 mg over 2 h; 5-fluorouracil 350 mg over 24 h	Concurrent	SCC	II(9); III(24); IV(12)	CRTS	22	-	-	-	24	2
								SA	23	-	-	-
Tepper等[15]	2008	USA	50.4 Gy, 1.8 Gy per fraction over 5.6 wk	Two cycles: cisplatin 100 mg/m2 1 d; fluorouracil 1 000 mg/(m2·d ) 1-4 d	Concurrent	SCC(25%); AC(75%)	T1-3, Nx	CRTS	30	28/2	59.9	53.76	72	2
								SA	26	23/3	62.2	21.48
彭林等[16]	2008	China	40 Gy, 2 Gy per fraction over 4 wk	Two cycles: cisplatin 75 mg/m2 1 d; 5-fluorouracil 500 mg/m2 over 5d	Concurrent	SCC	IIB; III	CRTS	40	30/40	58.4	30	37.5	3
								SA	40	32/8	57.5	24
金明根等[17]	2008	China	38-44 Gy, 2 Gy per fraction, total 19-22 fractions	Paclitaxe 135 mg/m2, 1 d,22; cisplatin 20-30 mg/m2, dl-5, 22-26 d	Concurrent	SCC(92%); AC(8%)	II(26); III(36)	CRTS	30	22/8	49	-	-	3
								SA	30	20/10		-
Cao等[18]	2009	China	40 Gy, 2 Gy per fraction over 4 wk	cisplatin 20 mg/(m2·d) ds1-5; fluorouracil 500 mg/(m2·d) 1-5 d; mitomycin 10 mg/(m2·d) 1 d	Concurrent	SCC	II(15); III(211); IV(10)	CRTS	118	60/58	-	59	-	2
								SA	118	67/51	-	43
吕进等[19]	2009	China	40 Gy, 2 Gy/d, 1-5 d, 8-12, 15-19, 22-26	Two cycles: Paclitaxe 125 mg/m2, l d;	Concurrent	SCC	IIb(15); III(213); IV(10)	CRTS	119	61/58	-	30.5	-	2
				cisplatin 20 mg/m2, 1-3 d				SA	119	68/51	-	18.3
Lv等[20]	2010	China	40 Gy, 2 Gy per fraction over 4 wk	Two cycles: cisplatin 20 mg/(m2·d), 1-3 d, 22-25; paclitaxel 135 mg/m2 starting on 1 d, 22 of radiotherapy	Concurrent	SCC	II(71); III(89)	CRTS	80	52/28	-	53	45	2
								SA	80	50/30	-	36
谢军等[21]	2010	China	45-5l Gy, 2 Gy per faction, 1-5 d/wk, total 2l-25 fractions	5-fluorouracil 2.4 g/m2 l-3 d, 22-24; cisplatin 75 mg/m2, 1 d, 22	Concurrent	SCC	II(22); III(47); IVa(1)	CRTS	35	27/8	50	-	-	3
								SA	35	25/10		-
张文山等[22]	2011	China	40 Gy, 1.8-2.0 Gy per fraction over 4 wk	Two cycles 5-fluorouracil 500 mg/m2, 1-5 d; cisplatin 30 mg/(m2·d)	Concurrent	-	III	CRTS	29	18/11	50.4	40	-	3
								SA	40	26/14	52.2	29
金芳玲等[23]	2011	China	50 Gy, 2 Gy per fraction over 5 wk mg/(m2·d), 1-5 d	Two cycles: cisplatin 75 mg/(m2·d), d1; 5-fluorouracil 500 mg/(m2·d), 1-5 d	Concurrent	SCC(92%); AC(8%)	IIa(10); IIb(9); III(41)	CRTS	30	18/12	54	34	-	2
								SA	30	21/9		22
van Hagen 等[24]	2012	Netherlands	41.4 Gy, 1.8 Gy per fraction over 4.6 wk	5 wk chemotherapy; carboplatin area under curve = 2 and paclitaxel 50 mg/m2 on 1 d weekly	Concurrent	SCC(23%); AC(75%)	T1N1 or T2-3N0-1M0	CRTS	178	134/44	60	49.4	45.4	2
								SA	188	152/26	60	24
杨弘等[25]	2012	China	40 Gy, 2 Gy per fraction over 4 wk	Two cycles: navelbine 25 mg/m2 1,8,22,29 d;cisplatin 75 mg/m2 1,22 d	Concurrent	SCC	IIB(20) III(113)	CRTS	54	46/8	54	-	-	3

SCC: 鳞癌; AC: 腺癌; CRTS: 术前放化疗; SA: 单纯手术; -: 文中未提及.