临床研究
Copyright ©The Author(s) 2009.
世界华人消化杂志. 2009-01-28; 17(3): 273-278
在线出版 2009-01-28. doi: 10.11569/wcjd.v17.i3.273
表1 VDR基因型分布 n(%)
分组n基因型
BBBbbbBB+Bb
病例组504(8.0)6(12.0)40(80.0)10(10.0)
对照组7219(26.4)10(13.9)43(59.7)29(40.3)
合计12223(18.9)16(13.1)83(68.0)39(32.0)
OR31.6671.5502.6980.371
95% CI7.983-125.6180.516-4.6571.167-6.2350.160-0.857
P0.0280.0010.4350.0200.018
表2 等位基因分布 n(%)
分组等位基因
OR95% CIPearson列联系数
bB
病例组86(86.0)14(14.0)
对照组96(66.7)48(33.3)3.0711.583-3.9580.213
合计182(74.6)72(25.4)
表3 多因素非条件Logistic回归模型中各因素的赋值方式
研究因素变量赋值
年龄(岁)X1<45 = 1, 45-54 = 2, 55-64 = 3, >65 = 4
性别X2女 = 0, 男 = 1
饮酒状况X3不饮酒 = 0, 饮酒 = 1
基因型X4Bb = 0, BB = 1, bb = 2
ALTX5<50 U/L = 0, >50 U/L = 1
ASTX6<50 U/L = 0, >50 U/L = 1
ALT/ASTX7<1 = 0, >1 = 1
总胆红素X83.4-17.1 μmol/L = 0, >17.1 μmol/L = 1
结合胆红素X90-6.8 μmol/L = 0, >6.8 μmol/L = 1
非结合胆红素X101.7-17.1 μmol/L = 0, >17.1 μmol/L = 1,
CHOLX113.60-5.70 mmol/L = 0, >5.70 mmol/L = 1
TGX120.80-1.80 mmol/L = 0, >1.80 mmol/L = 1
HDLX130.80-1.08 mmol/L = 0, >1.08 mmol/L = 1
LDLX141.55-3.70 mmol/L = 0, >3.70 mmol/L = 1
透明质酸(HA)X1550.0-120.0 mg/L = 0, >120.0 mg/L = 1
层黏蛋白(LN)X1690.0-133.0 μg/L = 0, >133.0 μg/L = 1
人型前胶原(HacⅢ)X17<120.0 μg/L = 0, >120.0 μg/L = 1
Ⅳ型胶原(Ⅳ.C)X18<84.7 μg/mL = 0, >84.7 μg/mL = 1
结合胆酸(SCG)X19<290.0 μg/mL = 0, >290.0 μg/mL = 1
是否患酒精性肝病Y对照 = 0, 患者 = 1
表4 进入方程中的自变量及有关参数的估计值
入选变量回归系数b标准误SbWaldΧ2POR95% CI For OR
LowerUpper
X39.61329.0100.1100.74014964.1200.0007.4E+28
X40.8210.4343.5800.0582.2720.9715.318
X53.6491.08511.3190.00138.4394.587322.120
常数项-11.48729.0180.1570.6920.000

引文著录: 孙平, 王沁. 维生素D受体基因多态性与酒精性肝病的相关性. 世界华人消化杂志 2009; 17(3): 273-278