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©The Author(s) 2007.
世界华人消化杂志. 2007-06-08; 15(16): 1825-1829
在线出版 2007-06-08. doi: 10.11569/wcjd.v15.i16.1825
在线出版 2007-06-08. doi: 10.11569/wcjd.v15.i16.1825
表1 非酒精性脂肪性肝病组基因型分布
| 分组 | n | 基因型 | 基因型 | χ2 | P | |||
| A (c1/c1) | B (c1/c2) | C (c2/c2) | c1 | c2 | ||||
| 非酒精性脂肪性肝病 | 40 | 12(30.0%) | 23(57.5%) | 5(12.5%) | 47(58.8%) | 33(41.2%) | ||
| 酒精性肝病对照 | 20 | 6(30.0%) | 12(60.0%) | 2(10.0%) | 24(60.0%) | 16(40.0%) | 0.017 | 0.896(>0.05) |
| 非脂肪肝对照 | 20 | 13(65.0%) | 7(35.0%) | 0 | 33(82.5%) | 7(17.5%) | 6.769 | 0.005(<0.05) |
| 正常对照 | 20 | 14(70.0%) | 6(30.0%) | 0 | 34(85.0%) | 6(15.0%) | 8.376 | 0.004(<0.05) |
表2 CYP2E1基因型与非酒精性脂肪性肝病的关系(n, %)
| 分组 | n | 基因型 | 基因型 | χ2 | P | |||
| A (c1/c1) | B (c1/c2) | C (c2/c2) | c1 | c2 | ||||
| 单纯性脂肪肝 | 13 | 10(76.9%) | 3(23.1%) | 0 | 23(88.5%) | 3(11.5%) | ||
| 脂肪性肝炎 | 10 | 1(10.0%) | 8(80.0%) | 1(10.0%) | 10(50.0%) | 10(50.0%) | 8.248 | 0.04(<0.05) |
| 肝硬化 | 17 | 1(5.9%) | 12(70.6%) | 4(23.5%) | 14(41.2%) | 20(58.8%) | 13.935 | 0.000(<0.05) |
表3 非酒精性脂肪肝不同伴发症基因型分布
| 分组 | n | 基因型 | 基因型 | χ2 | P | |||
| A (c1/c1) | B (c1/c2) | C (c2/c2) | c1 | c2 | ||||
| 肥胖 | 20 | 5(25.0%) | 13(65.0%) | 2(10.0%) | 23(57.5%) | 17(42.5%) | ||
| 糖尿病 | 20 | 7(35.0%) | 10(50.0%) | 3(15.0%) | 24(60.0%) | 16(40.0%) | 0.052 | 0.820(>0.05) |
引文著录: 郭艳梅, 王沁, 祁志. 细胞色素P4502E1酶与非酒精性脂肪肝的关系. 世界华人消化杂志 2007; 15(16): 1825-1829