三种抗病毒治疗方法对慢性乙型肝炎患者生活质量的影响

表1 三组患者一般情况的比较

分组	n	年龄(岁)	性别(男)%	病程(mo)
甲	56	30.5±9.6	68	198.0±173.3
乙	60	31.0±9.7	74	216.2±182.6
丙	27	27.5±9.1	42	208.6±155.6
P		0.107	0.766	0.518

表2 治疗前组间比较(mean±SD)

分组	n	GH	PF	RP	RE	SF	BP	V	MH	SF36
甲	56	49.11	91.16	65.18	64.88	57.37	76.65	64.20	72.43	71.41
		(19.82)	(7.63)	(38.04)	(38.36)	(16.99)	(16.92)	(15.43)	(13.53)	(11.91)
乙	60	50.42	85.83	63.33	63.33	63.33	79.04	65.75	71.20	70.21
		(21.58)	(14.71)	(40.77)	(38.67)	(22.06)	(19.34)	(19.09)	(15.18)	(15.59)
丙	27	55.93	86.48	52.78	56.79	67.22	80.28	60.56	73.33	69.42
		(22.41)	(18.34)	(40.63)	(42.18)	(25.26)	(18.56)	(20.16)	(15.01)	(17.71)
P		0.375	0.119	0.392	0.671	0.101	0.648	0.461	0.797	0.826

表3 治疗结束点组间比较(甲、乙组48 wk, 丙组24 wk, mean±SD)

分组	n	GH	PF	RP	RE	SF	BP	V	MH	SF36
甲	56	52.68	87.50	59.82	68.45	63.62	71.88	62.86	70.21	70.19
		(20.07)	(18.14)	(41.47)	(37.83)	(17.40)	(17.30)	(21.23)	(16.07)	(16.85)
乙	60	53.33	88.92	70.42	65.56	65.04	77.75	65.00	71.53	72.50
		(21.17)	(12.01)	(33.98)	(36.81)	(22.64)	(21.94)	(19.16)	(17.21)	(14.85)
丙	27	51.85	83.89	55.56	60.49	65.37	79.72	62.59	69.93	68.34
		(18.04)	(19.63)	(42.37)	(39.26)	(22.82)	(18.65)	(15.34)	(15.15)	(16.47)
P		0.950	0.418	0.296	0.637	0.910	0.145	0.793	0.876	0.498

表4 随访结束点组间比较(甲、乙组72 wk, 丙组48 wk, mean±SD)

分组	n	GH	PF	RP	RE	SF	BP	V	MH	SF36
甲	33	50.61	87.12	61.72	51.04	60.94	73.59	63.44	71.13	67.71
		(20.76)	(19.41)	(39.65)	(42.32)	(15.80)	(19.66)	(16.92)	(16.18)	(17.89)
乙	30	54.33	90.50	80.83	73.33	66.25	74.83	65.17	70.07	74.08
		(24.10)	(11.25)	(26.82)	(37.55)	(23.71)	(20.51)	(14.91)	(15.14)	(12.73)
丙	27	56.30	85.37	59.26	64.20	64.44	82.50	65.00	73.48	71.03
		(22.71)	(20.04)	(41.11)	(39.14)	(21.34)	(16.19)	(19.12)	(17.12)	(18.31)
P		0.608	0.523	0.100	0.091	0.583	0.166	0.908	0.723	0.314

表5 甲、乙、丙三组治疗前、治疗结束、随访结束不同时间点SF-36总分比较(mean±SD)

时间点	甲组	乙组	丙组
治疗前	71.41±11.91	70.21±15.59	69.42±17.71
治疗结束	70.19±16.85	72.50±14.85	68.34±16.47
随访结束	67.71±17.89	74.08±12.73	71.03±18.31
P	0.371	0.579	0.852

表6 治疗结束时病毒载量与对生活质量量表的关系(mean±SD)

病毒量copies/L	n	GH	PF	RP	RE	SF	BP	V	MH	SF36
<106	43	55.47	89.07	63.95	69.77	68.02	77.67	65.93	68.56	72.32
		(19.93)	(13.98)	(38.69)	(36.96)	(18.16)	(20.04)	(17.26)	(15.48)	(15.02)
106-108	53	51.98	87.08	62.74	61.64	61.13	76.32	62.45	74.04	70.33
		(18.95)	(14.59)	(38.49)	(37.78)	(20.32)	(17.70)	(19.45)	(15.42)	(15.31)
>108	35	54.86	85.57	65.71	69.52	67.21	76.36	67.71	69.60	71.64
		(20.27)	(22.45)	(39.34)	(36.49)	(21.66)	(18.58)	(17.25)	(16.70)	(17.06)
P		0.651	0.655	0.866	0.427	0.188	0.929	0.383	0.200	0.820