外源质粒DNA对小鼠肠道基因表达谱的影响

表1 质粒灌胃后4 h肠道中表达上调的基因

GenBank accession	Cy5/Cy3	Symbol	基因名称
NM_008638	2.3244	MTHFD2	亚甲基四氢叶酸脱氢酶, 次甲基四氢叶酸环水解酶
NM_019810	2.3264	SLC5A1	Solute carrier family 5, member 1 溶质载体家族
NM_011150	2.3762	LGALS3BP	Peptidylprolyl isomerase C-associated protein肽基脯氨酸异构酶C伴随蛋白
NM_007885	2.4262	SLC26A2	Solute carrier family 26 (sulfate transporter), member 2 溶质载体家族
AY008277	2.4573	CLCA4	Mus musculus calcium-activated chloride channel CLCA4 mRNA, complete cds
NM_021394	2.5322	ZBP1	Tumor stroma and activated macrophage protein DLM-1 肿瘤间质巨噬细胞蛋白
NM_022331	2.7	HERPUD1	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
NM_007672	2.7677	CDR2	Cerebellar degeneration-related 2 小脑退化基因
NM_010501	2.9068	IFIT3	Interferon-induced protein with tetratricopeptide repeats 3 干扰素诱导蛋白
BC013478	3.0711	SLC30A2	Mus musculus, clone IMAGE: 4239648, mRNA
NM_011036	3.1659	PAP	Pancreatitis-associated protein胰腺炎相关蛋白
BC005552	3.3969	ASNS	Asparagine synthetase天冬酰胺合成酶
AK002567	3.4149	MT2	Metallothionein 2金属硫蛋白2
NM_011260	4.2078	REG3G	Regenerating islet-derived 3 gamma再生基因
AF027131	4.5115	MUC3	Mucin 3, intestinal黏蛋白
BC007173	4.5371	TPP2	Mus musculus, clone IMAGE:3493127, mRNA, partial cds
NM_007769	4.6993	DMBT1	Crp-ductin候选肿瘤抑制基因
NM_007679	4.7027	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta CCAT增强子结合蛋白
NM_022411	5.3687	SLC13A2	Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 溶质载体家族
NM_011470	6.2025	SPRR2D	Small proline-rich protein 2D小脯氨酸富含蛋白
AK019097	11.7085	2310057M21RIK	RIKEN cDNA 2310057M21 gene
AK016647	20.4069	SLCO6C1	RIKEN cDNA 4933404A18 gene

表2 质粒灌胃后4 h肠道中表达下调的基因

GenBank accession	Cy5/Cy3	Symbol	基因名称
X78543	0.0829	MCPT-PS1	肥大细胞蛋白酶
NM_008339	0.1468	CD79B	免疫球蛋白基因
AK008016	0.1705	2010001M09RIK	RIKEN cDNA 2010001M09 gene
NM_009696	0.2125	APOE	Apolipoprotein E载脂蛋白E
NM_011402	0.2243	SLC34A2	Solute carrier family 34 (sodium phosphate), member 2溶质载体家族
NM_013492	0.2466	CLU	Clusterin簇集蛋白
NM_007398	0.2932	ADA	Adenosine deaminase腺苷脱氨酶
NM_010382	0.2964	H2-EB1	Histocompatibility 2, class II antigen E beta主要组织相容性抗原基因II
NM_007489	0.3206	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like芳烃受体核移位因子
NM_009042	0.3611	REG1	Regenerating islet-derived 1 再生基因
BC021548	0.3644	0610039P13RIK	RIKEN cDNA 0610039P13 gene
AY030094	0.3734	4932416A11RIK	Mus musculus von Willebrand factor A-related protein (Warp) mRNA, complete cds
NM_011468	0.376	SPRR2A	富含脯氨酸小蛋白
AK004658	0.39	HSPCA	热休克蛋白86
BC007144	0.4201	PSCDBP	Expressed sequence C80816
NM_021520	0.4247	SLC28A2	溶质载体家族28
NM_019411	0.425	PPP2CA	蛋白磷酸酯酶
BC011492	0.4303	9130020G10RIK	RIKEN cDNA 9130020G10 gene
M28739	0.4349	TUBB2	Tubulin, beta 2 微管蛋白
NM_009825	0.4648	SERPINH1	热休克蛋白47
NM_130450	0.4711	ELOVL6	Expressed sequence C77826
NM_009810	0.4712	CASP3	Caspase 3, apoptosis related cysteine protease
NM_009984	0.4725	CTSL	组织蛋白酶
NM_023114	0.4757	APOC3	Apolipoprotein CIII载脂蛋白C III