大鼠重症急性胰腺炎并发腹内压升高导致肺损伤

表1 SAP+IAH大鼠动脉血气 (mean±SD, n = 7, mmHg)

分组		PaO2	PaCO2
Control		98.8±4.2	39.2±2.4
SAP	1 h	95.8±3.2	39.3±2.1
	2 h	90.1±2.3	42.2±1.3
	4 h	80.7±1.7a	45.5±2.0
SAP+IAH 2 cmH2O	1 h	89.0±4.2ac	39.0±3.7
	2 h	84.8±2.9ac	42.6±1.0
	4 h	78.2±2.4ac	47.1±2.2
SAP+IAH 4 cmH2O	1 h	74.5±5.3ac	49.3±3.1ac
	2 h	69.0±4.0ac	52.9±5.5ac
	4 h	65.9±3.2bc	55.0±4.4ac
SAP+IAH 10 cmH2O	1 h	59.3±1.7bd	65.4±8.3bd
	2 h	53.5±5.0bd	69.7±7.8bd
	4 h	50.3±4.0bd	72.3±7.1bd

^aP<0.05,

^bP<0.01 vs 对照组;

^cP<0.05,

^dP<0.01 vs SAP组相应时间点.

表2 SAP+IAH肺组织湿质量/干质量比值 (mean±SD, n = 7)

分组	1 h	2 h	4 h
Control	4.1±0.1	4.2±0.1	4.4±0.2
SAP	4.9±0.6a	5.0±0.4a	5.8±0.2a
SAP+IAH 2 cmH2O	5.1±0.3b	5.4±0.5b	6.1±0.8b
SAP+IAH 4 cmH2O	5.5±0.4bc	5.8±0.7bd	6.5±0.3bd
SAP+IAH 10 cmH2O	6.2±0.1bd	6.8±0.1bd	6.9±0.1bd

^aP<0.05,

^bP<0.01 vs 对照组;

^cP<0.05,

^dP<0.01 vs SAP组.