探讨老年胃癌患者胃液中TNF-α, CA19-9和CEA联合检测的临床价值

表1 老年患者胃液中各项指标的检测水平比较(mean±SD)

分组	n	TNF-α (mg/L)	CA19-9 (IU/L)	CEA (mg/L)
甲	30	4.92±1.24	36.89±11.23	17.55±3.82
乙	31	5.66±1.25	38.73±9.23	19.42±5.19
丙	42	8.96±2.10b	59.47±10.58b	31.68±5.58b

^bP<0.001 vs 甲组、乙组.

表2 老年患者胃液中各项指标检测结果的评价指标

检测指标	灵敏度(%)	特异度(%)	阳性预期值(%)	阴性预期值(%)	阳性似然比
TNF-α	69.1	75.4	65.9	77.9	2.81
CA19-9	65.7	67.2	58.3	74.6	2.03
CEA	61.9	70.5	59.1	72.9	2.09

表3 老年患者胃液中各项指标的联合检测

组合方式	灵敏度(%)	特异度(%)	阳性预期值(%)	阴性预期值(%)	阳性似然比
1, 2	69.8	72.5	61.7	72.2	2.23
1, 3	73.7	76.2	77.9	74.3	3.02
2, 3	68.2	71.3	60.2	71.4	2.18
1, 2, 3	97.4	89.3	93.4	85.3	3.96

1: TNF-α; 2: CA19-9; 3: CEA.