5-羟色胺转运体基因多态性与肠易激综合征的相关性

表1 SERT基因5-HTTLPR及VNTRs多态性位点基因型频数和等位基因频数分布

分组	n	启动子区5-HTTLPR n(％)							内含子2 VNTRs n(％)
		S/S	L/S	L/L	L/XL	S	L	XL	12/12	12/10	10/10	12	10
D-IBS	51	29	15	5	2	73	27	2	43	7	1	93	9
		(56.9)	(29.4)	(9.8)c	(3.9)	(71.6)	(26.4)c	(2.0)	(84.3)	(13.7)	(2.0)	(91.2)	(8.8)
C-IBS	58	21	19	18	0	61	55	0	45	10	3	100	16
		(36.2)a	(32.8)	(31.0)		(52.6)	(47.4)a		(77.6)	(17.2)	(5.2)	(86.2)	(13.8)
A-IBS	38	14	15	9	0	43	33	0	32	4	2	68	8
		(36.8)	(39.5)	(23.7)		(56.6)	(43.4)		(84.2)	(10.5)	(5.3)	(89.5)	(10.5)
对照组	48	24	20	4	0	68	28	0	35	11	2	81	15
		(50.0)	(41.7)	(8.3)		(70.8)	(29.2)		(72.9)	(22.9)	(4.2)	(84.4)	(15.6)

^aP<0.05 vs 对照组;

^cP<0.05 vs C-IBS.