Copyright
©The Author(s) 2004.
世界华人消化杂志. 2004-03-15; 12(3): 689-693
在线出版 2004-03-15. doi: 10.11569/wcjd.v12.i3.689
在线出版 2004-03-15. doi: 10.11569/wcjd.v12.i3.689
表1 SD大鼠肝硬化手术后FPP的变化(n = 10, mean±SD, kPa)
手术 | MCS | DSCS | PAD |
前 | 1.46±0.07 | 1.45±0.05 | 1.45±0.06 |
后 | 1.10±0.03b | 1.41±0.04 | 1.43±0.05 |
表2 SD大鼠肝硬化手术死亡情况(n = 10,%)
表3 SD鼠肝硬化手术后PSS的变化(n = 8,%)
表4 SD大鼠肝硬化手术后肝功能的变化(n = 10)
分组 | ALT(Iu/L) | TP(g/L) | ALB(g/l) | G (g/L) | A/G |
NL | 12±6b | 72.6±3.3a | 35.6±2.5b | 37.0±2.5 | 0.97±0.13b |
CL | 30±7 | 67.0±2.4 | 26.7±2.7 | 40.3±2.7 | 0.67±0.11 |
MCS1 | 53±9b | 59.2±4.2b | 20.5±3.3b | 38.7±3.3 | 0.53±0.10 |
DSCS1 | 31±8d | 63.3±3.4 | 24.2±2.7 | 39.2±3.1 | 0.62±0.10 |
PAD1 | 66±14bf | 58.1±3.6be | 22.0±2.3a | 36.1±2.8 | 0.61±0.09 |
MCS2 | 57±10b | 56.1±5.0b | 18.5±2.6b | 37.6±4.7 | 0.50±0.10a |
DSCS2 | 31±7d | 64.2±3.6d | 25.0±2.2d | 39.2±3.2 | 0.64±0.09 |
PAD2 | 48±7bf | 60.4±2.9a | 23.3±2.5d | 37.1±3.1 | 0.63±0.10 |
MCS3 | 61±11b | 53.7±5.0b | 16.9±1.8b | 36.8±4.8 | 0.47±0.09a |
DSCS3 | 31±7d | 64.8±3.2d | 25.5±2.5d | 39.3±3.4 | 0.66±0.10d |
PAD3 | 31±7d | 64.2±3.5d | 25.3±2.7d | 38.9±3.1 | 0.66±0.10d |
表5 SD大鼠肝硬化手术后肝脏线粒体功能的变化(n = 8)
分组 | S3 S4 | RCR | P/O | ATP(mol/g) | |
nmolO2/min/mg | |||||
NL | 125.03±13.48 | 30.29±2.36b | 4.12±0.23b | 1.74±0.08b | 2.25±0.15b |
CL | 115.05±3.82 | 38.66±2.78 | 2.99±0.25 | 1.57±0.06 | 1.45±0.29 |
MCS1 | 106.05±13.77 | 55.00±4.98b | 1.93±0.23b | 1.25±0.05b | 0.38±0.10b |
DSCS1 | 118.65±0.39 | 41.34±3.46d | 2.88±0.20d | 1.53±0.05d | 0.95±0.08bd |
PAD1 | 115.15±4.70 | 46.66±3.93bd | 2.48±0.19bed | 1.34±0.11be | 0.93±0.09bd |
MCS2 | 111.86±4.76 | 49.26±1.72b | 2.23±0.18b | 1.33±0.10b | 0.68±0.08b |
DSCS2 | 113.08±6.27 | 38.56±1.67 d | 2.94±0.25d | 1.56±0.04d | 1.38±0.24d |
PAD2 | 113.94±4.93 | 42.26±3.37d | 2.73±0.23d | 1.51±0.08d | 1.35±0.23d |
MCS3 | 113.14±6.09 | 44.58±1.99b | 2.54±0.16b | 1.36±0.06b | 0.92±0.08b |
DSCS3 | 133.23±7.53 | 38.48±1.47d | 2.95±0.24c | 1.56±0.05d | 1.43±0.29d |
PAD3 | 111.53±7.34 | 38.50±2.10d | 2.91±0.26c | 1.57±0.15d | 1.42±0.28d |
表6 SD大鼠肝硬化手术后肝组织巯基含量的变化(n = 8, mean±SD, mol/g)
组别 | T-SH | NP-SH | P-SH |
NL | 28.20±2.25b | 8.29±0.69a | 19.92±2.67a |
CL | 23.88±3.71 | 6.43±0.92 | 17.42±2.45 |
MCS1 | 13.24±1.51b | 4.84±1.26a | 8.40±1.44b |
DSCS1 | 21.14±2.14 bd | 6.56±0.40d | 14.58±2.23bd |
PAD1 | 17.96±1.84 bdf | 4.31±0.85bf | 13.65±1.59bd |
MCS2 | 17.50±1.80b | 5.26±1.65 | 12.24±2.06b |
DSCS2 | 23.40±2.69d | 5.95±1.69 | 17.46±1.43d |
PAD2 | 20.82±2.89 bde | 6.73±0.74 | 14.08±1.08bf |
MCS3 | 17.65±2.98b | 4.80±1.23a | 12.84±1.75b |
DSCS3 | 23.63±2.59d | 6.34±1.20 | 17.29±1.11d |
PAD3 | 21.35±2.07 ade | 6.45±0.97c | 14.90±1.39be |
表7 SD大鼠肝硬化手术后肝组织SOD活性和LPO含量的变化(u/mg) (n = 8, mean±SD)
指标 | 术式 | 术前 | 术后(wk) | |||
NL | CL | 1 | 2 | 3 | ||
MCS | 66.45±26.74b | 124.58±16.54b | 161.56±8.77b | |||
SOD(u/mg) | DSCS | 238.16±16.94b | 193.59±13.80 | 135.06±11.48bd | 163.89±8.13bd | 191.22±11.54d |
PAD | 135.71±12.28bd | 162.51±8.45bd | 191.70±10.93d | |||
MCS | 0.39±1.45b | 5.78±0.31b | 4.44±0.35b | |||
LPO(mmol/g) | DSCS | 2.36±0.29b | 3.35±0.46 | 4.46±0.36bd | 3.44±0.42d | 3.37±0.43d |
PAD | 4.54±0.39bd | 3.47±0.39d | 3.40±0.42d |
引文著录: 徐新保, 蔡景修, 董家鸿, 何振平, 韩本立, 冷希圣. 肝硬化大鼠门静脉高压症不同手术方式对其肝脏的影响. 世界华人消化杂志 2004; 12(3): 689-693