大黄与促肝细胞生长素联合治疗重型肝炎

表1 两组疗效比较

组别	n	显效	有效	无效	死亡	有效率(%)
治疗组	18	7	4	3	4	61.11
对照组	17	3	3	4	7	35.29
P值						<0.01

表2 不同时间2组血清中肝功、血氨、LPS及细胞因子的变化(mean±SD)

组别	ALT (U/L)	TBiL (mmol/L)	LPS (mg/L)	血氨 (mmol/L)	IL-6 (mg/L)	IL-8 (mg/L)	TNF-α (mg/L)
治疗组
0 wk	418.85±251.74	413.27±115.61	63.78±22.31	163.24±67.23	97.23±6.15	323.56±24.52	4.78±0.54
2 wk	284.13±64.81	221.62±78.36	33.24±18.54	121.37±32.21	74.28±4.36	271.25±17.84	3.68±0.75
4 wk	83.25±33.17 a	103.35±75.51a	22.74±15.37a	77.23±35.64b	62.34±5.37a	188.86±16.54a	2.84±0.66a
6 wk	56.31±36.32 a	64.34±56.28a	16.68±9.31b	51.64±34.17b	49.58±5.16a	138.83±12.67b	2.35±0.23b
对照组
0 wk	427.26±273.65	395.37±103.82	63.81±25.46	166.33±65.83	95.38±6.84	337.35±25.74	4.81±0.48
2 wk	325.26±138.12	244.32±94.04	39.81±29.58	131.45±57.24	76.58±5.06	284.52±22.94	3.71±0.68
4 wk	126.62±81.52	165.83±94.27	36.07±21.24	116.45±46.73	67.42±5.81	202.28±19.78	3.31±0.45
6 wk	89.73±57.41	113.36±67.23	28.21±12.36	87.14±35.48	54.36±5.68	151.41±13.68	2.81±0.63

^aP<0.05,

^bP<0.01 vs 对照组.