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Protein modifications and inflammatory bowel disease
Na Zhao, Biao Huang, Qiao-Feng Wu, Yong Tang, Shu-Guang Yu
Na Zhao, Biao Huang, Qiao-Feng Wu, Yong Tang, Shu-Guang Yu, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
Supported by: National Natural Science Foundation of China, No. 81373737 and No. 81330087; Youth Fund of Science and Technology Department of Sichuan Province, No. 2015JQO058; Fok Ying-Tong Education Foundation, No. 141041.
Correspondence to: Qiao-Feng Wu, Researcher, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, 37 Shi'erqiao Road, Jinniu District, Chengdu 610075, Sichuan Province, China. 20052023@cdutcm.edu.cn
Received: March 31, 2017 Revised: April 11, 2017 Accepted: May 2, 2017 Published online: June 18, 2017
In recent years, the incidence of inflammatory bowel disease (IBD) has risen, but the cause and mechanism of IBD are not clear. Evidence shows that abnormal expression of proteins in the intestine is associated with the pathogenesis of IBD. Protein modifications refer to post-translational modifications that can change the spatial conformation, activity, and stability of proteins as well as their interactions with other molecules, which participate in many biological processes. Although protein modifications do not change the DNA sequence, they can affect the expression of related genes. Studies have shown that diet, environment, intestinal microbes and other factors can alter protein modifications to affect the pathogenesis of IBD. This article reviews the role of protein modifications in the pathogenesis of IBD.
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