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MicroRNAs as biomarkers for colorectal cancer: recent advances
Jian-Jun Yang, Yan-Lei Ma, Huan-Long Qin
Jian-Jun Yang, Yan-Lei Ma, Huan-Long Qin, Department of Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
Supported by: the Science and Technology Program of Shanghai City, No. 07DZ19505.
Correspondence to: Professor Huan-Long Qin, Department of Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China. huanlong_qin@live.cn
Received: December 11, 2009 Revised: January 12, 2010 Accepted: January 19, 2010 Published online: February 28, 2010
MicroRNAs (miRNAs) are a class of short non-coding RNAs (19-24 nucleotides in length). They can inhibit protein translation and induce degradation of target mRNAs, and thus play an important role in the regulation of gene expression. Recent studies have identified miRNAs in colorectal cancer (CRC) tissue and blood that may help accurately diagnose the presence of CRC, predict disease recurrence, and evaluate clinical and pathological features of CRC. Overexpression and silencing of specific miRNAs are associated with the development and progression of CRC. The differential expression of miRNAs in CRC tissue and blood offer the prospect for their use in early detection and screening of the disease. In addition, miRNAs may be important targets for gene therapy of CRC. In this paper, we will review the potential role of miRNAs as biomarkers for diagnosis and treatment of CRC.
Key Words: MicroRNA; Colorectal cancer; Biomarker
Citation: Yang JJ, Ma YL, Qin HL. MicroRNAs as biomarkers for colorectal cancer: recent advances. Shijie Huaren Xiaohua Zazhi 2010; 18(6): 568-575
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