CTP-HBcAg18-27-Tapasin诱导C57BL/6小鼠HBV特异性CTL反应的机制

图1 各组T淋巴细胞上清液中细胞因子水平. A: IFN-γ; B: IL-2; C: IL-4; D: IL-10. 1: CTP-HBcAg_18-27-Tapasin; 2: CTP-HBcAg_18-27-Tapasin+AG490; 3: AG490; 4: PBS. ^bP<0.01 vs PBS组; ^dP<0.01 vs AG490组; ^fP<0.01 vs CTP-HBcAg_18-27-Tapasin+AG490组. CTP: 胞质转导肽; IL: 白介素; IFN-γ: 干扰素-γ.

图2 各组小鼠T淋巴细胞增殖活性. 1: CTP-HBcAg_18-27-Tapasin; 2: CTP-HBcAg_18-27-Tapasin+AG490; 3: AG490; 4: PBS. ^bP<0.01 vs PBS组; ^dP<0.01 vs AG490组; ^fP<0.01 vs CTP-HBcAg_18-27-Tapasin+AG490组. CTP: 胞质转导肽.

图3 各组CD8⁺/IFN-γ⁺双阳性细胞数百分比. 1: CTP-HBcAg_18-27-Tapasin; 2: CTP-HBcAg_18-27-Tapasin+AG490; 3: AG490; 4: PBS. ^bP<0.01 vs PBS组; ^dP<0.01 vs AG490组; ^fP<0.01 vs CTP-HBcAg_18-27-Tapasin+AG490组. CTP: 胞质转导肽; IFN-γ: 干扰素-γ.

图4 各组JAK/STAT信号通路分子mRNA相对表达量. ^aP<0.05, ^bP<0.01 vs PBS组; ^cP<0.05, ^dP<0.01 vs AG490组; ^eP<0.05, ^fP<0.01 vs CTP-HBcAg_18-27-Tapasin+AG490组. CTP: 胞质转导肽.