Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia

Table 1 IgA Levels in blood plasma and small intestinal mucous membrane

	Blood plasma IgA (ug/ml)	Mucosal tissue IgA (ug/g)
Control Group	146.73 ± 50.98a	507.48 ± 167.39c
Group TPN	133.94 ± 64.41b	544.62 ± 100.78d
Group LPS	194.52 ± 111.18	611.89 ± 171.60
Group Gln	255.13 + 160.59	827.89 + 279.96

Note: Values were expressed as mean ± SD;

^aP < 0.02, vs Gln group;

^bP < 0.04, vs Gln group;

^cP< 0.01, vs Gln group;

^dP < 0.02, vs Gln group; There 's a positive correlation for IgA levels in blood plasma and mucosal tissues (r = 0.961, P < 0.04).

Table 2 Correlation of IgAs with interleukins

	IgA of blood plasma			IgA of mucous membrane
	IL-4	IL-6	IL-10	IL-4	IL-6	IL-10
r value	-0.562	-0.584	0.744	-0.614	-0.373	-0.396
P value	0.438	0.416	0.256	0.386	0.627	0.604
Correlationa	no	no	no	no	no	no

Note: Values were expressed as mean ± SD; ^aThere was no correlations between each IgA level in plasma and mucosal tissue with that of three interleukins respectively in intestinal mucosa.

Table 3 Bacteriologic tests

	MLN	Liver	PVB	Rate of BT	Logarithm of TB
Control group	3/8	0/8	0/8	12.5% (3/24)a	0.5414 + 1.4799d
TPN group	4/9	4/9	4/9	44.4% (12/27)	2.3279 + 2.3609
LPS group	5/8	6/8	7/8	75.0% (18/24)b	3.07822.2824e
Gln group	2/8	5/8	3/8	41.7% (10/24)c	1.5845 + 2.3209

Note: Values were expressed as mean ± SD; MLN, mesenteric lymph node; PVB, portal vein blood; BT, bacterial translocation; TB, translocated bacteria; BTR, rate of BT;

^aP < 0.01, vs TPN group and LPS group;

^bP < 0.02, vs Gln group;

^cP < 0.03, vs group control;

^dP < 0.01, vs TPN group and LPS group;

^eP < 0.01, vs Gln group; The rate of bacterial translocation is positively correlated to the logarithm of the number of translocated bacteria (r = 0.978, P < 0.022, P < 0.03).