Study on the classification of chronic gastritis at molecular biological level

doi:10.3748/wjg.v9.i4.836

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Apr 15, 2003 (publication date) through Mar 10, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Apr 15, 2003; 9(4): 836-842
Published online Apr 15, 2003. doi: 10.3748/wjg.v9.i4.836

Table 1 Degree of inflammatory cell infiltration compared with the degree of decrease of original glands in gastric mucosa n (%)

Group	n	Degree of inflammatory cell infiltration			Degree decrease of glands propria
Group	n	< 1/3	> 1/3 < 2/3	> 2/3	< 1/3	1/3 < 2/3	> 2/3
NC	15
CSG-woS	18	11 (61.1)	6 (33.3)	1 (5.6)	1 (5.6)
CAG-woS	9	5 (55.6)	3 (33.3)	1 (11.1)	5 (55.6)^d	3 (33.3)
F-TwS	56
CSG-wS	68	26 (38.2)^c	32 (47.1)	10 (14.7)
CAG-Ws	64	19 (29.7)^d^f	21 (32.8)	24 (37.5)^d^f	23 (35.9)^d	23 (35.9)	18 (28.1)

Compared with NC group. ^aP < 0.05, ^bP < 0.01; compared with CSG-woS group.

^cP < 0.05,

^dP < 0.01; compared with CAG-woS group. ^eP < 0.05,

^fP < 0.01, Compared with F-wS group, ^gP < 0.05, ^hP < 0.01, Compared with CSG-wS group, ⁱP < 0.05, ^jP < 0.01, In table 2-6, the marks are the same as here.

Table 2 Focal background lesions in non-focal site of gastric mucosa n (%)

Focal lesions	CSG-woS (n = 18)		CAG-woS (n = 9)		CSG-wS (n = 68)		CAG-Ws (n = 64)
Focal lesions	Gastric antrum	Gastric body	Gastric antrum	Gastric body	Gastric antrum	Gastric body	Gastric antrum	Gastric body
Atrophic	1 (5.6)	0 (0.0)	1 (11.1)^a	0 (0.0)	21 (30.9)^bd	11 (16.2)	47 (73.4)^bdj	27 (42.2)^j
inflammatory lesion
IM	4 (22.2)	1 (5.6)	5 (55.6)^b	2 (22.2)^b	27 (39.7)^bc	5 (7.4)^d	59 (92.2)^bdj	13 (20.3)^b
Micro ulcer	1 (5.6)	1 (5.6)	3 (33.3)^b	1 (11.1)^a	11 (16.2)	2 (2.9)^c	28 (43.8)^bdj	9 (14.1)^aj

Table 3 Ultrastructures of gastric mucosa epithelial cell nuclei n (%)

Group	n	Appeararce		Chromatin		Nucleoli
Group	n	Nucleoplasmic ratio > 1	Nuclear lobulation	margination or homogeneity	Perinuclear concentration	hypertrophy or margination	looping
NC	15			1 (6.7)	1 (6.7)
CSG-woS	18	1 ( 5.6)		4 (22.2)^b	1 (5.6)	1 (5.6)	1 (5.6)
CAG-woS	9	2 (22.2)^d	2 (22.2)	7 (77.8)^bd	3 (33.3)^bd	2 (22.2)^d	4 (44.4)^d
F-TwS	56			3 (5.4)^df	3 (5.4)^f	1 (1.8)^f
CSG-wS	68	5 ( 5.7)^f	2 (2.9)^f	7 (10.3)^cf	5 (7.4)^f	2 (2.9)^f	2 (2.9)^f
CAG-Ws	64	20 (31.3)^dj	9 (29.7)^j	33 (51.6)^bdhj	29 (45.3)^dfhj	27 (42.2)^dfhj	14 (21.9)^dgi

Table 4 Mitochondria ultrastructures of gastric mucosa epithelial cells. (x^-± s)

Group	n	Number	Swelling & overgrowth (%)	Matrix-discoloration (%)	Vacuolar degencration (%)	Pyknosis (%)	Crista number	Crista fragmentation & derangement (%)
NC	15	86.5 ± 27.3	3.4 ± 1.6	3.0 ± 1.1	2.9 ± 1.9	1.1 ± 0.8	12.8 ± 3.2	2.2 ± 1.1
CSG-woS	18	85.3 ± 22.2	3.9 ± 1.1	3.9 ± 2.2	3.2 ± 1.2	1.4 ± 0.9	11.4 ± 2.4	3.1 ± 1.3
CAG-woS	9	83.8 ± 17.3	4.4 ± 2.4	4.3 ± 2.9	3.3 ± 1.1	1.7 ± 0.8	11.4 ± 2.1	3.2 ± 1.2
F-TwS	56	83.1 ± 22.8	5.4 ± 2.9^bd	4.4 ± 2.4	2.9 ± 1.8	1.2 ± 0.7	11.2 ± 2.3	3.9 ± 1.2^bc
CSG-wS	68	65.4 ± 21.1^bdfh	7.2 ± 3.8^bdfg	7.9 ± 5.0^bdfh	6.4 ± 4.5^bdfh	1.9 ± 0.9^bch	8.2 ± 3.2^bdfh	5.8 ± 3.1^bdfh
CAG-wS	64	52.2 ± 20.8^bdfhj	10.9 ± 4.5^bdfhj	11.7 ± 8.6^bdfhj	11.6 ± 7.7^bdfhj	3.7 ± 1.1^bdfhj	6.9 ± 3.5^bdfhji	8.9 ± 3.7^bdfhj

Table 5 Gastric mucosa trace elements, cAMP and ³H-TdRLCT (x^-± s)

Group	n	Gastric mucosa				Blood ³H-TdRLCT (Bq/L)
Group	n	Zn (WT%)	Cu (WT%)	cAMP (Pmol/g)	SOD (u/g)	Blood ³H-TdRLCT (Bq/L)
NC	15	4.1 ± 1.0	5.2 ± 0.8	15.9 ± 1.5	170.5 ± 6.1	1079.7 ± 227.4
CSG-woS	18	3.7 ± 1.2	5.1 ± 1.8	15.6 ± 0.9	167.2 ± 5.3	924.5 ± 234.9
CAG-woS	9	3.3 ± 1.0	4.8 ± 0.9	14.9 ± 0.7^a	166.1 ± 4.2^a	887.7 ± 243.6
F-TwS	56	3.5 ± 1.4^a	4.5 ± 1.0^a	15.7 ± 1.4^e	167.9 ± 5.7	932.1 ± 2449.3^a
CSG-wS	68	2.8 ± 1.9^bcg	4.0 ± 1.5^aceg	14.2 ± 1.8^bdeh	163.3 ± 5.6^bdh	867.3 ± 240.5^bc
CAG-wS	64	2.0 ± 1.8^bdfhi	3.4 ± 1.5^bdfhj	13.4 ± 1.8^bdfhi	161.2 ± 4.3^bdfhi	800.9 ± 221.8^bdi

Table 6 Epithelial nuclei and mitochondria Zn, Cu in gastric mucosa (x^-± s)

Group	n	Nuclei			Mitochondria		Serum
Group	n	Zn (AT%)	Cu (AT%)	DNA (IOD)	Zn (AT%)	Cu (AT%)	LPO (umol/L)
NC	15	7.6 ± 0.4	58.4 ± 0.3	12.6 ± 2.7	9.2 ± 0.5	58.3 ± 0.3	2.6 ± 0.6
CSG-woS	18	7.8 ± 0.3	58.6 ± 0.4	13.0 ± 3.1	8.9 ± 0.5	58.2 ± 0.3	2.9 ± 0.4
CAG-woS	9	7.8 ± 0.3^a	58.7 ± 0.3^a	14.3 ± 2.8	8.8 ± 0.4^a	57.5 ± 0.2^bd	3.1 ± 0.4
F-TwS	56	7.9 ± 0.4^a	58.7 ± 0.5^a	13.5 ± 4.6	8.9 ± 0.5^a	58.0 ± 0.3^af	2.9 ± 0.7
CSG-wS	68	8.1 ± 0.5^bdfh	58.9 ± 0.5^bdh	15.2 ± 3.2^bcg	8.6 ± 0.5^bh	57.8 ± 0.3^bdfh	4.2 ± 0.7^bdfh
CAG-Ws	64	8.6 ± 0.4^bdfhj	59.3 ± 0.5^bdfhj	16.5 ± 3.1^bdehi	8.3 ± 0.4^bdfhj	57.5 ± 0.3^bdhj	4.5 ± 0.6^bdfhi

Citation: Yin GY, Zhang WN, He XF, Chen Y, Shen XJ. Study on the classification of chronic gastritis at molecular biological level. World J Gastroenterol 2003; 9(4): 836-842
URL: https://www.wjgnet.com/1007-9327/full/v9/i4/836.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i4.836