Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals

Table 1 Effect of CNP on spontaneous contraction of gastric antral smooth musle in various animals (^-x±s)

Species	n	Change of strip motility
		Amplitude (%)	Frequency (%)
Guinea-pig(C)	6	-58.23 ± 6.21ad	-10.81 ± 3.14
Guinea-pig(L)	6	-100.00 ± 0.00a	-100.00 ± 0.00a
Rat(C)	8	-66.32 ± 7.32abe	-10.76 ± 3.21
Rat(L)	8	-100.00 ± 0.00a	-100.00 ± 0.00a
Human(C)	4	-100.00 ± 0.00ac	-100.00 ± 0.00a
Human(L)	4	-100.00 ± 0.00a	-100.00 ± 0.00a

C: circular muscle; L: longitudinal muscle.

^aP < 0.01 vs pretreatment;

^bP < 0.05 vs Guinea-pig (C)group;

^cP < 0.01 vs Guinea-pig (C) group and Rat (C) group;

^dP < 0.01 vs Guinea-pig (L) group;

^eP < 0.01 vs Rat (L)group.

Table 2 Effect of CNP on spontaneous contraction of gastric fundus smooth muscle in various animals (^-x±s)

Species	n	Change of strip motility
		Amplitude/%	Frequency/%
Guinea-pig (C)	6	-76.77 ± 6.21a,b	-12.21 ± 3.23
Guinea-pig (L)	6	-100.00 ± 0.00a	-100.00 ± 0.003a
Rat (C)	8	-95.87 ± 4.12ace	-94.81 ± 5.19c
Rat (L)	8	-100.00 ± 0.00a	-100.00 ± 0.00a

C: circular muscle; L: longitudinal muscle;

^aP < 0.01 vs pre-treatment; ^aP < 0.01 vs Guinea-pig (L) group;

^cP < 0.01 vs Guinea-pig(C) group;

^eP < 0.01 vs Rat(L)group.

Table 3 Effect of LY83583 and Zaparinast on CNP-induced inhibition in gastric circular smooth musle of rat (^-x±s)

Group	n	Percentage of inhibition (%)
CNP1	5	63.61 ± 3.68
CNP1+LY	5	54.15 ± 2.97a
CNP2	5	65.67 ± 3.17
CNP2+Zap	5	77.67 ± 5.86b

^aP < 0.05 vs CNP1group; ^aP < 0.05 vs CNP2 group.