Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism

Table 1 Histological grading

Group	Grade
	0	1	2	3	4	5	6
Normal	7
Model		3	1	2	2	2a
CS		4	5ab

^aP < 0.05 vs normal control group,

^bP < 0.05 vs model control group.

Table 2 Serum content of HA, LN, ALT and AST (^-x±s)

Groups	HA (μg/L)	LN (μg/L)	ALT (U/L)	AST(U/L)
Normal	142.4 ± 51.0	41.6 ± 2.2	63.6 ± 11.9	108.6 ± 27.7
Model	316.5 ± 94.1a	59.7 ± 9.8a	224.3 ± 178.9a	272.6 ± 130.1a
CS	202.0 ± 79.3ab	50.4 ± 3.0ab	86.0 ± 34.4b	146.7 ± 60.2b

^aP < 0.05 vs normal control group,

^bP < 0.05 vs model control group.

Table 3 Staining index of procollagen I, III mRNA, TGFβ₁, TGFβ₁ mRNA, PDGF and PDGF mRNA in liver tissues (^-x±s)

Groups	ProcolI mRNA	ProcolIII mRNA	TGFβ1	TGF1 mRNA	PDGF	PDGF mRNA
Model	2.64 ± 1.40	0.95 ± 0.65	1.73 ± 1.40	3.17 ± 1.17	1.91 ± 0.74	0.70 ± 0.46
CS	1.10 ± 0.84a	0.36 ± 0.27c	0.2 ± 0.14a	1.68 ± 0.47a	0.87 ± 0.43b	0.35 ± 0.34c

^aP < 0.05,

^bP < 0.01, and

^cP > 0.05, vs model control group.