Expression of MUC1 in esophageal squamous-cell carcinoma and its relationship with prognosis of patients from Linzhou city, a high incidence area of northern China

Table 1 Survival analysis of high-expression and low-expres-sion of MUC1 in ESC

Expression of MUC1	No. of specimens examined	No. of death	Mean survival period (month) x (95%CI*)
Low-expression	42	17	52 (45, 59)
High-expression	72	40	41 (35, 47)
Total	114	57

*: Confidence Interval; Log-rank: χ² = 5.11, P = 0.0238.

Table 2 Relationship between the expression of MUC1 and regional lymph node metastasis

Group	No. of specimen examined	Expression of MUC1 protein
		- n(%)	+ n(%)	++ n(%)	+++ n(%)
Without metastasis	77	19 (24.7)	29 (37.7)	7 (9.1)	22 (28.5)
With Metastasis	37	0 (0)	4 (10.8)	5 (13.5)	28 (75.7)
Total	114	19	33	12	50

Chi-squared test: χ² =27.4693, P < 0.05.

Table 3 All factors employed by Cox regression model

Factors	Variable
Sex	X1	0 = male, 1 = female
Age	X2	0 ≤ 45 years, 1 = 45~55 years, 2 ≥ 55 years
Invading depth	X3	0 = lamina propria or submucosa, 1 = muscularis propria, 2 = adventitia, 3 = adjacent structures
Regional lymph node metastasis	X4	0 = no, 1 = yes
Distant metastasis	X5	0 = no, 1 = yes
TNM stage	X6	0 = 0, 1 = I, 2 = II, 3 = III, 4 = IV
Differentiation	X7	0 = high, 2 = moderate, 3 = low
Expression of MUC1	X8	0 = low, 1 = high

Table 4 Results of Cox model stepwise regression analysis

Variable	Parameter Estimated	Standard error	R	RR
X6	0.6217	0.1549	0.1717	1.8621
X7	0.8057	0.1961	0.1763	2.2382
X8	0.6632	0.3075	0.0311	1.9409