Effects of Rheum tanguticum polysaccharide on TNBS -induced colitis and CD4+ T cells in rats

Table 1 Effects of RTP₁ (200 mg·kg^-1, ig) on rats with TNBS -induced colitis (n = 10, x^-±s)

t/d	Colon mass index (mg·g-1)				Ulcerative area (%)
	Normal	Model	RTP1	DX	Normal	Model	RTP1	DX
5	2.8 ± 0.4	7.0 ± 1.4d	5.2 ± 1.4a	5.5 ± 0.6a	0.0 ± 0.0	35.7 ± 12.9d	16.1 ± 12.1b	26.2 ± 4.1a
7		6.9 ± 1.7d	5.4 ± 0.7a	5.6 ± 0.4a		44.5 ± 12.0d	31.8 ± 8.6a	35.7 ± 2.4a
10		7.3 ± 1.5d	5.2 ± 1.8a	5.2 ± 0.6b		27.5 ± 13.7d	17.7 ± 5.3a	22.1 ± 4.9
14		5.4 ± 0.9d	3.4 ± 0.8b	4.1 ± 0.3b		21.8 ± 9.7d	12.7 ± 4.1a	13.5 ± 2.7a

^aP < 0.05,

^bP < 0.01 vs Model;

^dP < 0.01 vs Normal.

Table 2 Effects of RTP₁ on SOD and MPO activity of colon in rats with TNBS- induced colitis (n = 10, x^-±s)

t/d	SOD (NU·g-1)				MPO (U·g-1)
	Normal	Model	RTP1	DX	Normal	Model	RTP1	DX
5	40.9 ± 7.7	48.7 ± 8.4c	69.1 ± 16.1b	72.5 ± 13.5b	0.09 ± 0.02	9.7 ± 3.2d	2.9 ± 1.9b	4.8 ± 1.0d
7		54.7 ± 7.8d	66.0 ± 6.8b	67.2 ± 12.1b		7.7 ± 1.5d	3.1 ± 0.8b	6.1 ± 1.1e
10		44.4 ± 7.9	63.4 ± 4.8b	60.1 ± 5.4b		6.0 ± 1.9d	4.3 ± 0.9a	4.3 ± 1.1a
14		38.8 ± 5.7	60.7 ± 10.5b	60.2 ± 6.4b		4.1 ± 1.2d	1.8 ± 0.5b	2.9 ± 0.8e

^aP < 0.05,

^bP < 0.01 vs Model.

^cP < 0.05,

^dP < 0.01 vs Normal.

^eP < 0.01 vs RTP₁.

Table 3 Effects of RTP₁ on thymus, spleen and body mass in rats with TNBS- induced colitis (n = 10, x^-±s)

t/d	Body mass (g)				Spleen index (mg·g-1)				Thymus index (mg·g-1)
	Normal	Model	RTP1	DX	Normal	Model	RTP1	DX	Normal	Model	RTP1	DX
5	242 ± 16	210 ± 26b	235 ± 32	215 ± 27d	2.3 ± 0.4	3.2 ± 0.4d	3.0 ± 0.4d	3.0 ± 0.6d	2.4 ± 0.03	0.9 ± 0.3d	1.2 ± 0.5d	0.7 ± 0.2d
7	255 ± 23	223 ± 39c	243 ± 24	196 ± 21bde		3.9 ± 1.0d	3.6 ± 0.6d	2.3 ± 0.2		1.1 ± 0.5d	1.3 ± 0.5d	0.6 ± 0.3bd
10	277 ± 29	252 ± 27	267 ± 38	176 ± 33bde		2.6 ± 0.2c	2.7 ± 0.5	2.4 ± 0.2		1.0 ± 0.4d	1.2 ± 0.4d	0.4 ± 0.7bd
14	278 ± 30	258 ± 22c	272 ± 31	165 ± 31bde		2.7 ± 0.3c	2.5 ± 0.6	1.8 ± 0.3bd		1.2 ± 0.3d	1.4 ± 0.2d	0.02 ± 0.01bd

^aP < 0.05,

^bP < 0.01 vs Model;

^cP < 0.05,

^dP < 0.01 vs Normal;

^eP < 0.05, ^fP < 0.01 vs RTP₁.