H Pylori
Copyright ©The Author(s) 2003.
World J Gastroenterol. Oct 15, 2003; 9(10): 2232-2235
Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2232
Table 1 Histologic features evaluated on each slide and score scale
Histologic featuresScoreGrading
Chronic inflammation0, none0, none
1, < 10 cic*/HPF**1-2-3, mild
2, > 10 cic/HPF4-5-6, moderate to marked
3, some areas with dense cic
4, diffuse infiltration with dens cic
5, nearly whole mucosa contains a dense cic
6, entire mucosa contains a dense cic infiltrate
Inflammatory activity0, none0, none
1, only one crypt involved/biopsy1-2, mild
2, two crypts involved/biopsy3-4-5-6, moderate to marked
3, many crypts (< 25%) involved/biopsy
4, 25%-50% of crypts involved/biopsy
5, > 50% of crypts involved/biopsy
6, all crypts involved
Atrophy0, none0, none
1, foci where a few gastric glands are lost or replaced by ie1-2, mild
2, small areas in which gastric glands3-4-5-6, moderate to marked
have disappeared or been replaced by ie
3, < 25% of gastric glands lost or replaced by ie
4, 25%-50% of gastric glands lost or replaced by ie
5, > 50% of gastric glands lost or replaced by ie
6, only a few small areas of gastric glands remaining
Intestinal metaplasia0, none0, none
1, only one crypt replaced by ie1-2-3, mild
2, one focal area (1-4 crypts) in one of two biopsies4-5-6, moderate to marked
3, two separate foci
4, multipl foci in one or both biopsies
5, > 50% of gastric epithelium diffusely replaced by ie
6, only a few small area of gastric epithelium are not replaced by ie
H pylori0, none0, none
1, H pylori found only in one place1-2-3-4, mild
2, only a few H pylori found5-6, moderate to marked
3, scattered H pylori found in separate areas/foci
4, numerous H pylori in separate areas/foci
5, nearly complete gastric surface covered by a layer of H pylori
6, continuous gastric surface coverage by a thick layer of H pylori
Surface epithelial damage0, none0, none
1, slight1-2-3-4, mild
2, mild deg in the top of the epithelial cells5-6, moderate to marked
3, moderate deg with disorientation of the epithelial lining
4, indistinct cell borders at the surface of the epithelium
5, flattened epithelial cells with severe deg and enlarged nuclei
6, flattened to erosive epithelium of the entire surface
Table 2 Kappa values and their 95% confidence intervals between three pathologists for H pylori gastritis
VariablePairwise analysis between pathologists
1:2
1:3
2:3
Kappa95%CIKappa95%CIKappa95%CI
Chronic inflammation0.49a0.13-0.85-0.34NS0.14NS
Inflammatory activity0.44a0.13-0.71-0.13NS-0.27NS
Atrophy0.31a0.83-0.560.03NS0.14NS
Intestinal metaplasia0.51a0.25-0.850.52a0.20-0.800.62a0.40-0.85
H pylori0.40a0.10-0.710.38a0.06-0.710.56a0.28-0.84
Surface epithelial damage-0.01NS----