Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer

Table 1 The distribution of genotypes of PGC gene polymorphism in health control, gastric cancer patients, and gastric cancer kindred group

Genotypes	Controls (Shenyang)	Gastric cancer patients	Controls (Zhuanghe)	Gastric cancer kindred
1:1	6 (0.14)	24 (0.33)	37 (0.33)	22 (0.36)
1:2	10 (0.24)	10 (0.14)	9 (0.08)	13 (0.21)
1:3	7 (0.17)	4 (0.05)	14 (0.12)	4 (0.07)
1:4	1 (0.02)	1 (0.01)	9 (0.08)	2 (0.03)
2:2	4 (0.10)	8 (0.11)	10 (0.09)	7 (0.11)
2:3	5 (0.12)	8 (0.11)	9 (0.08)	5 (0.08)
2:4	1 (0.02)	1 (0.01)	13 (0.12)	1 (0.16)
3:3	2 (0.05)	10 (0.14)	2 (0.02)	3 (0.05)
3:4	3 (0.07)	5 (0.07)	8 (0.07)	3 (0.05)
4:4	3 (0.07)	2 (0.03)	2 (0.02)	1 (0.16)
Total	42	73	113	61

Table 2 The frequency of four alleles of PGC gene polymorphism in health control, gastric cancer patients, and gastric cancer kindred group

	n	Alleles of PGC gene polymorphism
		1 (310 bp)	2 (400 bp)	3 (450 bp)	4 (480 bp)
Controls (Shenyang)	42	0.3571	0.2857	0.2262	0.1310
Gastric cancer patients	73	0.4315	0.2397	0.2534	0.0753
Controls (Zhuanghe)	113	0.4663	0.2389	0.1549	0.1504
Gastric cancer kindred	61	0.5164a	0.2705	0.1475	0.0656

^aP < 0.05 vs compared with control group of Shenyang χ² = 4.47.

Table 3 The distribution of allele 1 homogenotype in health control, gastric cancer patients, and gastric cancer kindred

	n	1:1	others
Controls (Shenyang)	42	6 (0.14)	36
Gastric cancer patients	73	24 (0.33)a	49
Controls (Zhuanghe)	113	37 (0.33)c	76
Gastric cancer kindred	61	22 (0.36)e	39

^aP < 0.05 vs compared with control group of Shenyang, χ² = 3.86; ^cP < 0.05 vs compared with control group of Shenyang, χ² = 4.32; ^eP < 0.05 vs compared with control group of Shenyang, χ² = 4.91.