Transfection of colorectal cancer cells with chemokine MCP-3 (monocyte chemotactic protein-3) gene retards tumor growth and inhibits tumor metastasis

Table 1 Tumor size in the mice inoculated with CMT93 or its gene transfectants (cm², ^-x±s)

Days after tumor injection	Tumor size in the mice inoculated with
	CMT93	CMT93/mock	CMT93/MCP-3
5	0.181 ± 0.020	0.170 ± 0.012	0.097 ± 0.012a
10	0.398 ± 0.030	0.397 ± 0.025	0.186 ± 0.019a
15	0.720 ± 0.185	0.751 ± 0.157	0.372 ± 0.104a
20	0.950 ± 0.303	0.954 ± 0.309	0.416 ± 0.167a
25	1.385 ± 0.222	1.335 ± 0.292	0.699 ± 0.170a
30	1.769 ± 0.371	1.680 ± 0.643	1.021 ± 0.253a

^aP < 0.05 vs CMT93 or CMT93/mock group

Table 2 Tumor metastasis in mice inoculated with CMT93 or its gene transfectants

Miceinoculated with	No. metastasized	No. not metastasized	Percentage(%)
CMT93	4	0	100
CMT93/Mock	4	1	80
CMT93/MCP-3	0	7	0ab

^aP < 0.001 vs CMT93 group;

^bP < 0.05 vs CMT93/Mock group