Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma

Table 1 The expression of bax, bcl-2 and bcl-xL mRNA in hepatocellular carcinoma and normal liver

	Hepatocellular carcinoma (21 cases)	normal liver (10 cases)	t value	P value
Bax	0.929 ± 1.233	7.060 ± 6.574	4.197	0.0002
Bcl-2	1.414 ± 1.331	5.930 ± 7.227	2.815	0.0087
Bcl-xL	2.433 ± 2.218	8.500 ± 5.743	4.277	0.0002

Table 2 The relationship between the expression of bax,bcl-2 and bcl-xL and clinical parameters of patients with hepatocel-lular carcinoma

		n	bax	bcl-2	bcl-xL
Age	≤ 65	10	0.980 ± 1.530	1.960 ± 1.678	3.020 ± 2.549
	> 65	11	0.882 ± 0.962	0.918 ± 0.663	1.900 ± 1.825
gender	male	13	1.100 ± 1.471	1.654 ± 1.532	2.600 ± 2.645
	female	8	0.650 ± 0.699	1.025 ± 0.871	2.163 ± 1.386
grading	well and moderate	12	0.975 ± 1.384	1.592 ± 1.540	2.775 ± 2.453
	poor and undifferentiated	9	0.867 ± 1.076	1.17 ± 1.028	1.978 ± 1.901
tumor stage	I II	6	0.583 ± 0.454	0.700 ± 0.616	2.000 ± 1.616
	III IV	15	1.067 ± 1.423	1.700 ± 1.445	2.607 ± 2.445

Statistical analysis revealed no relationship between bax,bcl-2 or bcl-xL expression and these parameters.