Expression of gastric cancer-associated MG7 antigen in gastric cancer, precancerous lesions and H. pylori-associated gastric diseases

Table 1 The expression of MG7 antigen in various gastric lessions

Gastric lessions	n	No. of cases with MG7expression				Positive rate(%)	Over-expression rate(%)
		–	+	++	+++
Normal	26	26	0	0	0	0.0b	0.0b
gastric mucosa
Intestinal	82	34	43	4	1	58.5bd	6.1b
metaplasia
Dysplasia	59	30	23	4	2	49.2bd	10.2b
Gastric cancer	57	5	23	18	11	91.2d	50.9d

^bP < 0.01 vs: compared with gastric cancer;

^dP < 0.01 vs: compared with normal gastric mucosa

Table 2 The expression of MG7 antigen in different gastric diseases

Gastric lessions	n	No. of cases withMG7expression				Positive rate(%)	Over-expression rate(%)
		–	+	++	+++
Superficial gastritis	67	59	7	0	1	11.9b	1.5b
Atrophic gastritis	71	25	39	7	0	64.8bd	9.9b
Gastric cancer	57	5	23	18	11	91.2d	150.9d

^bP < 0.01 vs: compared with gastric cancer;

^dP < 0.01 vs: compared with superficial gastritis

Table 3 The expression of MG7 in different types of intestinal metaplasia and gastric cancer

Types of intestinalmetaplasia	n	No. of cases with MG7expression				Positive rate(%)	Over-expression rate(%)
		–	+	++	+++
Type I and II intestinal metaplasia	53	28	24	1	0	47.2bb	1.9b
Type III intestinal metaplasia	29	6	19	3	1	79.3dd	13.8b
gastric cancer	57	5	23	18	11	91.2dd	50.9d

^bP < 0.01 vs compared with gastric cancer;

^bbP < 0.05 vs compared with gastric cancer;

^dP < 0.01 vs compared with superficial gastritis;

^ddP < 0.05 vs compared with superficial gastritis

Table 4 The expression of MG7 antigen in H. pylori-associated gastric lesions

Gastric lesions	H. pylori-positive			H. pylori-negative
	n	MG7 expression		n	MG7 expression
		No. of cases	rate (%)		No.of cases	rate (%)
superficial gastritis	39	8	20.5	27	0	a
gastric ulcer	12	3	25	8	1	12.5
atrophic gastritis	32	20	62.5	38	25	65.8
intestinal metaplasia	50	26	52.0	30	20	66.7
dysplasia	33	10	30.3	22	12	54.5

^aP < 0.05 vs compared with H. pylori-positive cases of the same gastric lesion

Table 5 The follow-up results of 34 cases with H. pylori-associ-ated gastric diseases

Change of H. pylori status	No.of cases	MG7 antigen expression
		mitigated	unchanged	aggravated	malignant change
H. pylori infection unchanged	19	4	13	1	1
H. pylori eradicated	14	4	7	1	2
H. pylori newly infected	1	0	0	1	0