The promoting molecular mechanism of alpha-fetoprotein on the growth of human hepatoma Bel7402 cell line

Table 1 The effects of AFP on the cell cycle progression. Bel 7402 cells maintained in RPMI 1640 medium were respectively treated with either AFP (20 mg·L^-1), anti-AFP (40 mg·L^-1), AFP (20 mg·L^-1) + anti-AFP (40 mg·L^-1) or HSA (20 mg·L^-1) for 24 hours. The effects of AFP on the cell cycle progression were analyzed by flow cytometry. The data represented the mean values of four independent experiments performed each in triplicate

Groups	G1 (%)	S (%)	G2 + M (%)
Control	37.0 ± 3.0	42.7 ± 2.8	19.2 ± 1.8
AFP	20.3 ± 1.6a	68.0 ± 4.2a	12.7 ± 1.3a
AFP + anti-AFP	32.0 ± 2.1	48.8 ± 2.51	9.2 ± 1.3
anti-AFP	34.61 ± 1.9	45.8 ± 2.5	19.6 ± 1.9
HSA	36.9 ± 4.3	43.2 ± 2.6	19.9 ± 2.4

^aP < 0.05 vs control group