p53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection

Table 1 Relationship between some clinicopathological parameters and overall survival rates of HCC patients (a univariate analysis)

Parameters	n	Overall survival rates%
		1-year	3-year	5-year
p53 expression
-	110	88.8	66.3	60.6
+	86	83.5	57.3	42.9
++	13	60.0	46.7
+++b	13	38.5	12.3
Tumors size (cm)
≤ 5 cm	122	92.6	69.0	55.8
> 5, ≤ 8 cm	50	78.0	63.0	55.1
> 8 cmb	50	60.0	23.9
Vascular invasion
No	160	88.7	68.5	60.7
Microscopic	36	80.6	47.0
Visual	26	42.3	7.5
Capsule
No	112	74.0	42.0	26.4
Wellb	110	90.5	75.9	75.9

^bP < 0.01

Table 2 Parameters affecting the disease-free survival rates of HCC patients (a univariate analysis)

Parameters	n	Disease-free survival rates (%)
		1-year	3-year	5-year
Vascular invasion
No	116	93.9	64.6	54.2
Yesa	22	72.7	37.0
Capsule
No	57	82.3	44.9	44.9
Yesb	81	96.3	73.2

^aP < 0.05,

^bP < 0.01, vs No.

Table 3 Relationship between some clinicopathological parameters and overall survival rates of HCC patients (a multivariate analysis)

	Correlation coefficient	Wald	Standard error	P
p53 expression	0.55	18.88	0.13	< 0.01
Tumor size	0.52	14.97	0.13	< 0.01
Vascular invasion	0.53	11.85	0.15	< 0.01
Tumor capsule	-0.87	10.30	-0.10	< 0.01