Effects of epidermal growth factor on the growth of human gastric cancer cell and the implanted tumor of nude mice

Table 1 The effect of rhEGF i.p. on the growth of MKN-28 tumor in nude mice

Group	Dosage	n	Body mass/g		Tumor mass -x±s/g	Inhibitary rate/%	P value
			Beginning	End
NS	0.2 mL	16	17.6	22.6	1.97 ± 0.94	——	——
MMC	2 μg·kg-1	8	17.8	20.0	0.47 ± 0.61	76.2	< 0.05
RhEGF	15 μg·kg-1	8	17.4	22.0	1.75 ± 0.81	11.1	< 0.05
RhEGF	30 μg·kg-1	8	17.9	23.8	1.91 ± 0.98	3.0	< 0.05
RhEGF	60 μg·kg-1	8	17.9	22.9	2.08 ± 1.56	-5.3	< 0.05

P value: compared with the NS group.

Table 2 The effect of rhEGF i.p. on the growth of SGC-7901 tumor in nude mice

Group	Dosage	n	Body mass/g		Tumor mass -x±s/g	Inhibitary rate/%	P value
			Beginning	End
NS	0.2 mL	16	14.4	25.2	1.07 ± 0.60	—	——
MMC	2 μg·kg-1	8	15.2	21.7	0.66 ± 0.29	38.6	< 0.05
RhEGF	15 μg·kg-1	8	15.9	25.3	1.53 ± 0.29	-43.8	< 0.05
RhEGF	30 μg·kg-1	8	14.1	23.8	1.07 ± 0.63	-0.7	< 0.05
RhEGF	60 μg·kg-1	8	13.4	23.9	1.20 ± 0.47	-12.5	< 0.05

P value: compared with the NS group.

Table 3 The effect of rhEGF i.p. on the growth of MKN-45 tumor in nude mice

Group	Dosage	n	Body mass/g		Tumor mass -x±s/g	Inhibitary rate/%	P value
			Beginning	End
NS	0.2 mL	20	16.1	19.8	1.82 ± 0.95	—	——
MMC	2 μg·kg-1	10	16.2	19.7	1.07 ± 0.42	41.1	< 0.05
RhEGF	15 μg·kg-1	10	16.0	20.3	1.92 ± 1.04	-5.5	< 0.05
RhEGF	30 μg·kg-1	10	16.5	19.8	1.29 ± 0.83	8.0	< 0.05
RhEGF	60 μg·kg-1	8	16.1	20.4	1.77 ± 1.04	3.1	< 0.05