RRR-α-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest

Table 1 Effect of VES on the viability of SGC-7901 cells

Group	Rate of viable cells/%
	1	2	3	4	5	6
UT control	100	100	100	100	100	100
VEH control	105.5	102.4	92.1	95.3	105.7	97.5
5 mg·L-1 VES	94.8	101.2	91.4	144.3	91.4	74.6
10 mg·L-1 VES	91.4	64.6	20.8	4.2	0	0
20 mg·L-1 VES	53.4	32.9	4.3	0	0	0

Table 2 Inhibitory effect of VES on DNA synthesis incorporated with ³H-TdR (^-x±s, n = 6)

Group	Radioactive intensity/Bq·104cell-1)
	24 h(% of inhibition ratio)	48 h(% of inhibition ratio)
UT control	64.1 ± 10.2(0)	143.2 ± 13.7(0)
VEH control	63.8 ± 10.3(1)	141.9 ± 14.7(0)
5 mg·L-1 VES	61.8 ± 10.4(4)	137.1 ± 16.3(4)
10 mg·L-1 VES	57.2 ± 10.7(11)	79.3 ± 10.0(45)b
20 mg·L-1 VES	41.4 ± 8.0(35)b	2.2 ± 0.3(98)b

^bP < 0.01, vs UT control.

Table 3 Induction of apoptosis after 48 h of VES treatment in SGC-7901 cells

Group	Apoptotic cells/104 cells	Rate of apoptosis/%
UT control	6	0.06
VEH control	28	0.28
5 mg·L-1 VES	1248b	12.48
10 mg·L-1 VES	5736b	57.63
20 mg·L-1 VES	8996b	89.96

^bP < 0.01, vs UT control.